Neuropsychiatric profiles of patients with juvenile myoclonic epilepsy treated with valproate or topiramate

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dc.contributor.author Araujo, GMD de
dc.contributor.author Pascalicchio, T. F.
dc.contributor.author Lin, K.
dc.contributor.author Sousa, P. S.
dc.contributor.author Yacubian, EMT
dc.date.accessioned 2016-01-24T12:41:10Z
dc.date.available 2016-01-24T12:41:10Z
dc.date.issued 2006-05-01
dc.identifier http://dx.doi.org/10.1016/j.yebeh.2006.01.016
dc.identifier.citation Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 8, n. 3, p. 606-609, 2006.
dc.identifier.issn 1525-5050
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28892
dc.description.abstract In this cross-sectional study, the neuropsychiatric profiles of 42 patients with juvenile myoclonic epilepsy (JME) who were treated with valproate (VPA) or topiramate (TPM) in monotherapy were compared with the aim of verifying the relationship between cognitive dysfunction, psychiatric disorders, and factors related to epilepsy. Patients with JME taking VPA 500-1750 mg/day or TPM 50-175 mg/day were selected. for all patients, psychiatric profiles were evaluated with the Scheduled Clinical Interview, axes I and II (SCID I and SCID II), or the Brazilian version of the Schedule for Affective Disorders and Schizophrenia for School-Aged Children (K-SADS-PL). Neuropsychological measures included intellectual functions, attention, memory, executive functions, and language. Patients taking TPM exhibited worse neuropsychological performance on attention, short-term memory, processing speed, and verbal fluency functions related to frontal lobes, which may be dysfunctional in JME. Anxiety disorders were associated with lack of seizure control and having had more than 20 lifetime generalized tonic-clonic seizures. (c) 2006 Elsevier Inc. All rights reserved. en
dc.format.extent 606-609
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Epilepsy & Behavior
dc.rights Acesso restrito
dc.subject juvenile myoclonic epilepsy en
dc.subject neuropsychological tests en
dc.subject psychiatric disorders en
dc.subject valproate en
dc.subject topiramate en
dc.title Neuropsychiatric profiles of patients with juvenile myoclonic epilepsy treated with valproate or topiramate en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UNIFESP, Escola Paulista Med, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifesp UNIFESP, Escola Paulista Med, Dept Neurol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.yebeh.2006.01.016
dc.description.source Web of Science
dc.identifier.wos WOS:000237716700021



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