Neuropsychiatric profiles of patients with juvenile myoclonic epilepsy treated with valproate or topiramate

Neuropsychiatric profiles of patients with juvenile myoclonic epilepsy treated with valproate or topiramate

Autor Araujo, GMD de Google Scholar
Pascalicchio, T. F. Google Scholar
Lin, K. Google Scholar
Sousa, P. S. Google Scholar
Yacubian, EMT Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo In this cross-sectional study, the neuropsychiatric profiles of 42 patients with juvenile myoclonic epilepsy (JME) who were treated with valproate (VPA) or topiramate (TPM) in monotherapy were compared with the aim of verifying the relationship between cognitive dysfunction, psychiatric disorders, and factors related to epilepsy. Patients with JME taking VPA 500-1750 mg/day or TPM 50-175 mg/day were selected. for all patients, psychiatric profiles were evaluated with the Scheduled Clinical Interview, axes I and II (SCID I and SCID II), or the Brazilian version of the Schedule for Affective Disorders and Schizophrenia for School-Aged Children (K-SADS-PL). Neuropsychological measures included intellectual functions, attention, memory, executive functions, and language. Patients taking TPM exhibited worse neuropsychological performance on attention, short-term memory, processing speed, and verbal fluency functions related to frontal lobes, which may be dysfunctional in JME. Anxiety disorders were associated with lack of seizure control and having had more than 20 lifetime generalized tonic-clonic seizures. (c) 2006 Elsevier Inc. All rights reserved.
Palavra-chave juvenile myoclonic epilepsy
neuropsychological tests
psychiatric disorders
valproate
topiramate
Idioma Inglês
Data de publicação 2006-05-01
Publicado em Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 8, n. 3, p. 606-609, 2006.
ISSN 1525-5050 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 606-609
Fonte http://dx.doi.org/10.1016/j.yebeh.2006.01.016
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000237716700021
Endereço permanente http://repositorio.unifesp.br/handle/11600/28892

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