Drug-induced home cage conspecifics' behavior can potentiate behavioral sensitization in mice

Drug-induced home cage conspecifics' behavior can potentiate behavioral sensitization in mice

Autor Araujo, N. P. Google Scholar
Fukushiro, D. F. Google Scholar
Cunha, J. L. S. Google Scholar
Levin, R. Google Scholar
Chinen, C. C. Google Scholar
Carvalho, R. C. Google Scholar
Ribeiro, I. C. P. Google Scholar
Gomes, D. C. Google Scholar
Abilio, V. C. Google Scholar
Silva, R. H. Google Scholar
Ribeiro, R. de A. Google Scholar
Frussa-Filho, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The effect of home cage conspecifics' behavior on locomotor sensitization to amphetamine (AMP) or ethanol (ETOH) were investigated. Female mice were repeatedly treated with saline or AMP (2.0 mg/kg for 13 days - Experiment 1) or saline or ETOH (1.8 g/kg for 21 days - Experiment 2) in home cages where all the animals had the same treatment (homogeneous home cages - HOM-HC) or in home cages where half of the animals were drug-treated and half of them were saline-treated (heterogeneous home cages - HET-HQ. Behavioral sensitization was evaluated by the quantification of open-field locomotor activity after AMP or ETOH challenge injection, respectively. in both experiments, behavioral sensitization was potentiated in HOM-HC maintained animals. These results suggest that the behavioral sensitization phenomenon can be modified by home cage conspecifics' behavior. (c) 2006 Elsevier Inc. All rights reserved.
Palavra-chave addiction
amphetamine
ethanol
open-field behavior
social learning
Idioma Inglês
Data de publicação 2006-05-01
Publicado em Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 84, n. 1, p. 142-147, 2006.
ISSN 0091-3057 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 142-147
Fonte http://dx.doi.org/10.1016/j.pbb.2006.04.019
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000239223400018
Endereço permanente http://repositorio.unifesp.br/handle/11600/28891

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