Prevalence and demographic characteristics of celiac disease among blood donors in Ribeirao Preto, State of São Paulo, Brazil

Prevalence and demographic characteristics of celiac disease among blood donors in Ribeirao Preto, State of São Paulo, Brazil

Autor Melo, Suzeidi Bernardo Castanheira Google Scholar
Fernandes, Maria Inez Machado Google Scholar
Peres, Luiz Cesar Google Scholar
Troncon, Luiz Ernesto Almeida Google Scholar
Galvao, Livia Carvalho Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Celiac disease (CD) is an underdiagnosed disease occurring in different clinical forms. This study aimed to determine the prevalence of CD among blood donors from Ribeirao Preto, Brazil, and to study some demographic characteristics of celiac patients. Blood samples from 3000 blood donors were tested for the presence of tissue transglutaminase antibody and positive samples were tested for endomysial antibody. Donors positive to both tests were referred for clinical evaluation and for a jejunal biopsy. Twenty-four samples were moderately/strongly positive for transglutaminase, with 9 of them being endomysial negative and 15 positive. of the 13 biopsies obtained from 12 females and 1 male, 1 was classified as Marsh grade IV, 4 as grade III, 2 as grade II, 4 as grade I, and 2 as grade 0. Estimated prevalence was therefore 1:273 (0.33%; 95% CI, 0.127 to 0.539). the 1:273 estimated prevalence of CD detected indicates that the disease is not rare in Brazil. the frequency was higher among females and among individuals of European descent, with a significantly higher frequency for a family history of digestive tract cancer or epilepsy.
Palavra-chave celiac disease
prevalence
antibodies
diagnosis
Idioma Inglês
Data de publicação 2006-05-01
Publicado em Digestive Diseases and Sciences. Dordrecht: Springer, v. 51, n. 5, p. 1020-1025, 2006.
ISSN 0163-2116 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 1020-1025
Fonte http://dx.doi.org/10.1007/s10620-006-9340-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000238847600034
Endereço permanente http://repositorio.unifesp.br/handle/11600/28878

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