CD4(+) CD25(+) T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells

CD4(+) CD25(+) T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells

Autor Campanelli, A. P. Google Scholar
Roselino, A. M. Google Scholar
Cavassani, K. A. Google Scholar
Pereira, MSF Google Scholar
Mortara, Renato Arruda Autor UNIFESP Google Scholar
Brodskyn, C. I. Google Scholar
Goncalves, H. S. Google Scholar
Belkaid, Y. Google Scholar
Barral-Netto, M. Google Scholar
Barral, A. Google Scholar
Silva, J. S. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Goncalo Moniz Res Inst
Inst Invest Immunol
Ctr Dermatol Dona Libana
NIH
Resumo Endogenous regulatory T ( T-reg) cells are involved in the control of infections, including Leishmania infection in mice. Leishmania viannia braziliensis is the main etiologic agent of cutaneous leishmaniasis ( CL) in Brazil, and it is also responsible for the more severe mucocutaneous form. Here, we investigated the possible involvement of T-reg cells in the control of the immune response in human skin lesions caused by L. viannia braziliensis infection. We show that functional T-reg cells can be found in skin lesions of patients with CL. These cells express phenotypic markers of T-reg cells-such as CD25, cytotoxic T lymphocyte-associated antigen 4, Foxp3, and glucocorticoid-induced tumor necrosis factor receptor-and are able to produce large amounts of interleukin-10 and transforming growth factor-beta. Furthermore, CD4(+) CD25(+) T cells derived from the skin lesions of 4 of 6 patients with CL significantly suppressed in vitro the phytohemagglutinin-induced proliferative T cell responses of allogeneic peripheral-blood mononuclear cells ( PBMCs) from healthy control subjects at a ratio of 1 T-reg cell to 10 allogeneic PBMCs. These findings suggest that functional Treg cells accumulate at sites of Leishmania infection in humans and possibly contribute to the local control of effector T cell functions.
Idioma Inglês
Data de publicação 2006-05-01
Publicado em Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 193, n. 9, p. 1313-1322, 2006.
ISSN 0022-1899 (Sherpa/Romeo, fator de impacto)
Publicador Univ Chicago Press
Extensão 1313-1322
Fonte http://dx.doi.org/10.1086/502980
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000237053300018
Endereço permanente http://repositorio.unifesp.br/handle/11600/28858

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta