Evidence for impaired insulin production and higher sensitivity in stunted children living in slums

Evidence for impaired insulin production and higher sensitivity in stunted children living in slums

Autor Martins, Paula Andrea Autor UNIFESP Google Scholar
Sawaya, Ana Lydia Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The objective of the present study was to investigate the changes in glucose and insulin metabolism in nutritionally stunted children that can be involved in the appearance of chronic diseases in adulthood. for this purpose, sixty-one children were selected, thirty-five boys and twenty-six girls, residents of slums in São Paulo, Brazil. the children were classified according to the height-for-age as stunted (l-1.5 Z-score; n 21) or non-stunted (>-1.5 Z-score; n 40). the glucose and insulin plasma levels were determined and, from these values, the indexes that evaluate the pancreatic beta-cell function (homeostasis model assessment (HOMA-B)) and insulin sensitivity (HOMA-S) were assessed. Stunted children showed lower values of fasting insulin than those of the non-stunted group (boys: 29.7 (sd 14.9) v. 50.4 (sd 29.2) pmol/l, P=0.019; girls: 34.4 (sd 12.6) v. 62.3 (sd 28.7) pmol/l, P=0.016) but the glucose levels were similar (boys: 4.6 (sd 0.3) v. 4.5 (sd 0.3) mmol/l; girls: 4.2 (sd 0.3) v. 4.4 (sd 0.3) mmol/l). Stunted children showed lower HOMA-B values (boys: 83 (sd 22) % v. 115 (sd 36) %, P=0.011; girls: 107 (sd 23) % v. 144 (sd 46) %, P=0.045) and higher HOMA-S values (boys: 196 (sd 92) % v. 120 (sd 62) %, P=0.014; girls: 159 (sd 67) % v. 98 (sd 57) %, P=0.016). the results show a decreased activity of beta-cell function and increased insulin sensitivity in stunted children. the decreased beta-cell function of this group may strongly predict type 2 diabetes.
Palavra-chave stunting
undernutrition
insulin sensitivity
beta-cell function
HOMA
Idioma Inglês
Data de publicação 2006-05-01
Publicado em British Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 95, n. 5, p. 996-1001, 2006.
ISSN 0007-1145 (Sherpa/Romeo, fator de impacto)
Publicador Cambridge Univ Press
Extensão 996-1001
Fonte http://dx.doi.org/10.1079/BJN20061754
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000236734500019
Endereço permanente http://repositorio.unifesp.br/handle/11600/28857

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