Fear conditioning performance and NMDA receptor subtypes: NR2A differential expression in the striatum

Fear conditioning performance and NMDA receptor subtypes: NR2A differential expression in the striatum

Autor Schenberg, E. E. Google Scholar
Ferreira, T. L. Google Scholar
Figueredo, L. Z. Google Scholar
Hipolide, D. C. Google Scholar
Nobrega, J. N. Google Scholar
Oliveira, MGM Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Ctr Addict & Mental Hlth
Resumo While considerable evidence implicates NMDA receptors in the hippocampus in contextual fear conditioning, the role of other brain regions is less well understood. To further investigate this issue, rats were subjected to a contextual fear conditioning task and then classified as high or low responders according to performance. Density of NMDA receptors was evaluated using [H-3]MK-801 autoradiography in 52 brain areas and expression of NR2A and NR2B subunits was studied with in situ hybridization in the same brains. Results revealed no differences between high- and low-performance rats in NMDA receptor binding in any of the brain areas studied. Similarly, NR2B subunit expression was also not different between groups. However, NR2A expression was significantly higher in the caudate-putamen of low-performance rats. These results suggest that NMDA receptors in the caudate-putamen may also be involved in contextual fear conditioning performance. (c) 2006 Elsevier Inc. All rights reserved.
Palavra-chave binding
fear conditioning
in situ hybridization
[H-3]MK-801
NMDA
NR2A
NR2B
Idioma Inglês
Data de publicação 2006-04-28
Publicado em Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 69, n. 4, p. 440-446, 2006.
ISSN 0361-9230 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 440-446
Fonte http://dx.doi.org/10.1016/j.brainresbull.2006.02.010
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000237361500011
Endereço permanente http://repositorio.unifesp.br/handle/11600/28852

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta