Liver retransplantation: A model for determining long-term survival

Liver retransplantation: A model for determining long-term survival

Autor Linhares, M. M. Google Scholar
Azoulay, D. Google Scholar
Matos, D. Google Scholar
Castelo, A. Google Scholar
Trivino, T. Google Scholar
Goldenberg, A. Google Scholar
Castaing, D. Google Scholar
Adam, R. Google Scholar
Delvart, V Google Scholar
Ichai, P. Google Scholar
Saliba, F. Google Scholar
Lemoine, A. Google Scholar
Samuel, D. Google Scholar
Bismuth, H. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hop Paul Brousse
Univ Paris Sud
Resumo Background. Because of the worse results from retransplantation in relation to the initial liver transplantation, there is a need to refine the indication for retransplantation, such that fair distribution of this benefit is obtained.Methods. This was a Study of 139 patients who underwent liver retransplantation. Thirty variables were studied: 18 relating to the recipient and 12 to the donor. All the independent variables were initially compared with the length of survival using univariate analyses. Variables presenting significance were compared with the dependent variable of length of survival, to determine which factors were related to longer survival among patients, when evaluated together.Results. A multivariate model for determining long-term survival among patients with retransplants was built up using the following variables: recipient's age, creatinine, urgency of retransplantation and early failure of the first graft. Through this multivariate model it was possible to determine a score that was categorized according to tertile distributions (below the 33rd percentile, score < 24; 33rd to 66th percentile, 24 <= score <= 32; above the 66th percentile, score > 32). One-year, 3-year, and 5-year patient survival rates following retransplantation were respectively 85%, 82%, and 77% for scores < 24; 69%, 66%, and 61% for scores between 24 and 32; and 21%, 19%, and 16% for scores > 32 (P < 0.0001).Conclusion. the variables of recipient's age, creatinine, urgency of retransplantation, and early failure of the initial transplantation were factors that were independently related to the long-term survival of patients with liver retransplants.
Assunto liver transplantation
risk factors
treatment failure
multivariate analysis
survival rate
Idioma Inglês
Data 2006-04-15
Publicado em Transplantation. Philadelphia: Lippincott Williams & Wilkins, v. 81, n. 7, p. 1016-1021, 2006.
ISSN 0041-1337 (Sherpa/Romeo, fator de impacto)
Editor Lippincott Williams & Wilkins
Extensão 1016-1021
Fonte http://dx.doi.org/10.1097/01.tp.0000203798.96491.2f
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000236958600015
URI http://repositorio.unifesp.br/handle/11600/28850

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