Sleep deprivation abolishes the locomotor stimulant effect of ethanol in mice

Sleep deprivation abolishes the locomotor stimulant effect of ethanol in mice

Autor Araujo, N. P. Google Scholar
Andersen, M. L. Google Scholar
Abilio, V. C. Google Scholar
Gomes, D. C. Google Scholar
Carvalho, R. C. Google Scholar
Silva, R. H. Google Scholar
Ribeiro, R. D. Google Scholar
Tufik, S. Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The present study aimed to investigate the effects of sleep deprivation (SD) on the dose-dependent stimulant effect of ethanol (ETOH) on the open-field behavior of female and male mice. Sleep-deprived (48 h, multiple platforms method) or home-cage control female mice were treated with saline (SAL) or 1.4, 1.8 or 2.2 g/kg ETOH 5 min before behavioral testing. ETOH produced a dose-dependent increase in open-field locomotor behavior. This locomotor stimulant effect did not reflect a general stimulation in motor activity, since it was accompanied by a simultaneous decrease in rearing frequency as well as by no modification in immobility duration. the effects of ETOH on these three behavioral parameters were specifically modified by SD: the locomotor stimulant effect was abolished, the rearing inhibitory effect was potentiated and the lack of effect on immobility was changed to increase in immobility. Similar results were obtained for male mice although the effects of SD had a lower magnitude. the present findings demonstrate that the acute effect of ETOH on mice's motor activity are behaviorally complex and can be specifically modulated by SD. (c) 2006 Elsevier Inc. All rights reserved.
Assunto open-field
alcohol
motor behavior
dopamine
GABA
Idioma Inglês
Data 2006-04-14
Publicado em Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 69, n. 3, p. 332-337, 2006.
ISSN 0361-9230 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 332-337
Fonte http://dx.doi.org/10.1016/j.brainresbull.2006.01.006
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000236660900013
URI http://repositorio.unifesp.br/handle/11600/28846

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