Role of the kinin B-1 receptor in insulin homeostasis and pancreatic islet function

Role of the kinin B-1 receptor in insulin homeostasis and pancreatic islet function

Autor Araujo, R. C. Google Scholar
Mori, M. A. Google Scholar
Merino, V. F. Google Scholar
Bascands, J. L. Google Scholar
Schanstra, J. P. Google Scholar
Zollner, R. L. Google Scholar
Villela, C. A. Google Scholar
Nakaie, C. R. Google Scholar
Paiva, ACM Google Scholar
Pesquero, J. L. Google Scholar
Bader, M. Google Scholar
Pesquero, J. B. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Mogi Cruzes
CHU Rangueil
Universidade Estadual de Campinas (UNICAMP)
Max Delbruck Ctr Mol Med
Resumo Kinins are potent vasoactive peptides generated in blood and tissues by the kallikrein serine proteases. Two distinct kinin receptors have been described, one constitutive subtype B-2) and one inducible (subtype B-1), and many physiological functions have been attributed to these receptors, including glucose homeostasis and control of vascular permeability. in this study we show that mice lacking the kinin B-1 receptor (B-1(-/-) mice) have lower fasting plasma glucose concentrations but exhibit higher glycemia after feeding when compared to wild-type mice. B-1(-/-) mice also present pancreas abnormalities, characterized by fewer pancreatic islets and lower insulin content, which leads to hypoinsulinemia and reduced insulin release after a glucose load. Nevertheless, an insulin tolerance test indicated higher sensitivity in B-1(-/-) mice. in line with this phenotype, pancreatic vascular permeability was shown to be reduced in B-1 receptor-ablated mice. the B-1 agonist desArg(9)bradykinin injected intravenously can induce the release of insulin into serum, and this effect was not observed in the B-1(-/-) mice or in isolated islets. Our data demonstrate the importance of the kinin B-1 receptor in the control of pancreatic vascular homeostasis and insulin release, highlighting a new role for this receptor in the pathogenesis of diabetes and related diseases.
Assunto diabetes
kinin B1 receptor
Idioma Inglês
Data 2006-04-01
Publicado em Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 387, n. 4, p. 431-436, 2006.
ISSN 1431-6730 (Sherpa/Romeo, fator de impacto)
Editor Walter de Gruyter & Co
Extensão 431-436
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000236955700012

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