Efficacy and tolerance of interferon-alpha in the treatment of chronic Hepatitis C in end-stage renal disease patients on hemodialysis

Efficacy and tolerance of interferon-alpha in the treatment of chronic Hepatitis C in end-stage renal disease patients on hemodialysis

Author Rocha, C. M. Google Scholar
Perez, R. M. Google Scholar
Ferreira, A. P. Google Scholar
Carvalho-Filho, R. J. Google Scholar
Pace, F. H. Google Scholar
Silva, I. S. Google Scholar
Pestana, JOM Google Scholar
Lanzoni, V. P. Google Scholar
Silva, A. E. Google Scholar
Ferraz, MLG Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Patients with end-stage renal disease (ESRD) show a high prevalence of hepatitis C, with a negative impact on the survival on hemodialysis and after renal transplantation. We evaluated the efficacy and tolerance of interferon-alpha (IFN-alpha) in HCV-infected ESRD patients on dialysis. Methods: Forty-six HCV-RNA-positive ESRD patients were studied. IFN-alpha regimen consisted of 3 million units three times a week for 12 months, and the patients were followed up for 6 months. End-of-treatment, and sustained biochemical and virological responses were evaluated and tolerance was assessed monthly. Results: A sustained virological response (SVR) was observed in 10/46 patients (22%) and in 10/29 who completed the treatment (34%). Alanine aminotransferase was elevated in 63% of the patients at the beginning of the study and returned to normal levels within the first month in all patients with SVR. Treatment was discontinued because of side effects in 11/46 patients (24%) and six patients (13%) were lost to follow-up. Conclusions: IFN-alpha monotherapy for hepatitis C in dialysis patients shows a high frequency of adverse effects. However, the SVR is high (34%) in patients who complete treatment, emphasizing the importance of careful selection and close follow-up in order to minimize and control possible side effects.
Keywords end-stage renal disease
hemodialysis
hepatitis C
interferon-alpha
liver
side effects
Language English
Date 2006-04-01
Published in Liver International. Oxford: Blackwell Publishing, v. 26, n. 3, p. 305-310, 2006.
ISSN 1478-3223 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 305-310
Origin http://dx.doi.org/10.1111/j.1478-3231.2005.01225.x
Access rights Closed access
Type Article
Web of Science ID WOS:000235868000006
URI http://repositorio.unifesp.br/handle/11600/28837

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