Paradoxical sleep deprivation and sleep recovery: Effects on the hypothalamic-pituitary-adrenal axis activity, energy balance and body composition of rats

Paradoxical sleep deprivation and sleep recovery: Effects on the hypothalamic-pituitary-adrenal axis activity, energy balance and body composition of rats

Autor Hipolide, D. C. Google Scholar
Suchecki, D. Google Scholar
Pinto, APD Google Scholar
Faria, E. C. Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Calif Riverside
Resumo Numerous studies indicate that sleep deprivation alters energy expenditure. However, this conclusion is drawn from indirect measurements. in the present study, we investigated alterations of energy expenditure, body composition, blood glucose levels, plasma insulin, adrenocorticotropic hormone (ACTH) and corticosterone levels immediately after 4 days of sleep deprivation or after 4 days of sleep recovery. Rats were sleep deprived or maintained in a control environment (groups sleep-deprived/deprivation and control/deprivation). One half of these animals were sacrificed at the end of the deprivation period and the other half was transported to metabolic cages, where they were allowed to sleep freely (groups sleep-deprived/recovery and control/recovery). At the end of the sleep recovery period, these rats were sacrificed. After sleep deprivation, sleep-deprived rats exhibited loss of body weight, augmented energy expenditure and reduced metabolic efficiency compared to control rats. These alterations were normalised during the sleep recovery period. the body composition of sleep-deprived rats was altered insofar as there was a loss of fat content and gain of protein content in the carcass compared to control rats. However, these alterations were not reversed by sleep recovery. Finally, plasma levels of insulin were reduced during the sleep deprivation period in both control and sleep deprived groups compared to the recovery period. After the deprivation period, plasma ACTH and corticosterone levels were increased in sleep-deprived rats compared to control rats, and although ACTH levels were similar between the groups after the sleep recovery period, corticosterone levels remained elevated in sleep-deprived rats after this period. By means of direct measurements of metabolism, our results showed that sleep deprivation produces increased energy expenditure and loss of fat content. Most of the alterations were reversed by sleep recovery, except for corticosterone levels and body composition.
Palavra-chave paradoxical sleep deprivation
sleep recovery
energy balance
body composition
hypothalamic-pituitary-adrenal axis
Idioma Inglês
Data de publicação 2006-04-01
Publicado em Journal of Neuroendocrinology. Oxford: Blackwell Publishing, v. 18, n. 4, p. 231-238, 2006.
ISSN 0953-8194 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 231-238
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235538800001
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