Performance of the DNA-Citoliq liquid-based cytology system compared with conventional smears

Performance of the DNA-Citoliq liquid-based cytology system compared with conventional smears

Author Alves, VAF Google Scholar
Castelo, A. Google Scholar
Filho, A. L. Google Scholar
Vianna, M. R. Google Scholar
Taromaru, E. Google Scholar
Namiyama, G. Google Scholar
Lorincz, A. Google Scholar
Dores, GBD Google Scholar
DNA-Citoliq Working Grp Google Scholar
Institution Adolfo Lutz Inst
Digene Corp
Digene Brasil
Hosp Alemao Oswaldo Cruz
Univ Minho
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Objective: To evaluate the performance of a new, manual, simplified liquid-based system, DNA-Citoliq (Digene Brasil), employed under routine conditions as compared to conventional smears collected from six collaborating private laboratories.Methods: A panel of cytopathologists, who served as the gold standard diagnosis, adjudicated discordant opinions.Results: of 3206 pairs of slides considered valid for comparison, there were 3008 in full agreement (93.8%), 112 (3.5%) with one diagnostic category discrepancies, and 86 (2.7%) discordant cases. Among the 288 borderline+ by either method, DNA-Citoliq detected abnormalities in 243 (84.4%), and conventional smears (CS) detected abnormalities in 178 (61.8%) (McNemar test, P < 0.000), a 36.5% increased detection of borderline+ cases.Conclusions: for mild dyskaryosis, DNA-Citoliq detected 176 cases and CS 125 cases (McNemar test, P < 0.000); and for moderate+severe dyskaryosis 66 versus 32 cases respectively (McNemar test, P < 0.000).
Keywords liquid-based cytology
DNA-Citoliq system
thin layer cytology
split-sample study
severe dyskaryosis
Language English
Date 2006-04-01
Published in Cytopathology. Oxford: Blackwell Publishing, v. 17, n. 2, p. 86-93, 2006.
ISSN 0956-5507 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 86-93
Access rights Closed access
Type Article
Web of Science ID WOS:000236176400006

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