Performance of the DNA-Citoliq liquid-based cytology system compared with conventional smears

Performance of the DNA-Citoliq liquid-based cytology system compared with conventional smears

Autor Alves, VAF Google Scholar
Castelo, A. Google Scholar
Filho, A. L. Google Scholar
Vianna, M. R. Google Scholar
Taromaru, E. Google Scholar
Namiyama, G. Google Scholar
Lorincz, A. Google Scholar
Dores, GBD Google Scholar
DNA-Citoliq Working Grp Google Scholar
Instituição Adolfo Lutz Inst
Digene Corp
Digene Brasil
Hosp Alemao Oswaldo Cruz
Univ Minho
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Objective: To evaluate the performance of a new, manual, simplified liquid-based system, DNA-Citoliq (Digene Brasil), employed under routine conditions as compared to conventional smears collected from six collaborating private laboratories.Methods: A panel of cytopathologists, who served as the gold standard diagnosis, adjudicated discordant opinions.Results: of 3206 pairs of slides considered valid for comparison, there were 3008 in full agreement (93.8%), 112 (3.5%) with one diagnostic category discrepancies, and 86 (2.7%) discordant cases. Among the 288 borderline+ by either method, DNA-Citoliq detected abnormalities in 243 (84.4%), and conventional smears (CS) detected abnormalities in 178 (61.8%) (McNemar test, P < 0.000), a 36.5% increased detection of borderline+ cases.Conclusions: for mild dyskaryosis, DNA-Citoliq detected 176 cases and CS 125 cases (McNemar test, P < 0.000); and for moderate+severe dyskaryosis 66 versus 32 cases respectively (McNemar test, P < 0.000).
Palavra-chave liquid-based cytology
DNA-Citoliq system
thin layer cytology
split-sample study
severe dyskaryosis
HPV
Idioma Inglês
Data de publicação 2006-04-01
Publicado em Cytopathology. Oxford: Blackwell Publishing, v. 17, n. 2, p. 86-93, 2006.
ISSN 0956-5507 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 86-93
Fonte http://dx.doi.org/10.1111/j.1365-2303.2006.00279.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000236176400006
Endereço permanente http://repositorio.unifesp.br/handle/11600/28832

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