Rebiopsy in patients with untreated hepatitis C: A useful procedure

Rebiopsy in patients with untreated hepatitis C: A useful procedure

Autor Khouri, Sandra Tuma Autor UNIFESP Google Scholar
Perez, R. M. Google Scholar
Oliveira, P. M. de Google Scholar
Figueiredo, V. M. Google Scholar
Barbosa, D. V. Google Scholar
Lanzoni, V. P. Google Scholar
Silva, AEB Google Scholar
Ferraz, M. L. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Resumo Background: the progression of fibrosis in the early stages of chronic hepatitis C virus is variable, and the ideal interval to perform a new biopsy in untreated patients is still unknown.Aims: We evaluated the histologic progression of patients with untreated hepatitis C virus with two liver biopsies and correlated disease progression with demographic, epidemiologic, biochemical, and histologic variables.Patients and Methods: Untreated hepatitis C virus-infected patients with two liver biopsies at a minimum interval of 1 year were studied. Gender, age, parenteral risk factors, duration of infection, alcohol intake, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, and histologic findings were analyzed.Results: Fifty-five patients were included. the first biopsy showed low grades of fibrosis and periportal necroinflammatory activity in 93%. A second biopsy was performed after 39 +/- 14 months; 40% of patients showed a progression of fibrosis and/or periportal necroinflammation. Comparison between groups with and without histologic worsening revealed no differences in demographic, epidemiologic, biochemical, or histologic data.Conclusions: Histologic worsening occurred in 40% of untreated patients after 3.2 years. No factor could be established at the first biopsy to predict which patients are at risk of progression. Thus, histologic reassessment between 3 and 5 years seems to be the only approach to document disease progression and establish treatment indication.
Palavra-chave hepatitis C
liver biopsy
liver fibrosis
natural history
Idioma Inglês
Data de publicação 2006-04-01
Publicado em Journal of Clinical Gastroenterology. Philadelphia: Lippincott Williams & Wilkins, v. 40, n. 4, p. 347-352, 2006.
ISSN 0192-0790 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 347-352
Fonte http://dx.doi.org/10.1097/01.mcg.0000210100.36500.3f
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000236992500013
Endereço permanente http://repositorio.unifesp.br/handle/11600/28831

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