Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases

Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases

Autor Fogaca, A. C. Google Scholar
Almeida, I. C. Google Scholar
Eberlin, M. N. Google Scholar
Tanaka, A. S. Google Scholar
Bulet, P. Google Scholar
Daffre, S. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Atheris Labs
Resumo The presence of an effective immune response in the hemocoel of arthropods is essential for survival as it prevents the invasion of pathogens throughout the animal body. Antimicrobial peptides (AMPs) play an important role in this response by rapidly killing invading microorganisms. in this study, a novel cysteine-rich AMP has been isolated and characterized from the hemocytes of the cattle tick, Boophilus microplus. in addition to growth inhibition of Escherichia coli and Micrococcus luteus, the newly described AMP, designated ixodidin (derived from the Family Ixodidae), was found to exert proteolytic inhibitory activity against two exogenous serine proteinases, elastase and chymotrypsin. This is the first report of a molecule of an arachnid that has been shown to inhibit bacterial growth and proteinase activity. (c) 2005 Elsevier Inc. All rights reserved.
Palavra-chave antimicrobial peptide
serine proteinase inhibitor
immune system
hemocyte
tick
Idioma Inglês
Data de publicação 2006-04-01
Publicado em Peptides. New York: Elsevier B.V., v. 27, n. 4, p. 667-674, 2006.
ISSN 0196-9781 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 667-674
Fonte http://dx.doi.org/10.1016/j.peptides.2005.07.013
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000237047000009
Endereço permanente http://repositorio.unifesp.br/handle/11600/28823

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