Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis

Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis

Autor Gales, A. C. Google Scholar
Sader, H. S. Google Scholar
Andrade, S. S. Google Scholar
Lutz, L. Google Scholar
Machado, A. Google Scholar
Barth, A. L. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
JMI Labs
Hosp Clin
Resumo We report the first linezolid-resistant Staphylococcus aureus strain isolated in Brazil. the strain was isolated from a 10-year-old female patient with cystic fibrosis (CF) who received repeated and prolonged courses of low-dose linezolid. the strain belonged to the Brazilian endemic methicillin-resistant S. aureus clone, and the G2576U mutation was identified in domain V of the 23S rRNA. Detection of this mechanism of resistance in a CF patient is very worrisome, as these patients may become a reservoir for further dissemination of resistant strains. Our findings emphasise the importance of optimal dosage of linezolid to prevent the emergence of resistance. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Palavra-chave Staphylococcus aureus
linezolid
drug resistance
cystic fibrosis
Idioma Inglês
Data de publicação 2006-04-01
Publicado em International Journal of Antimicrobial Agents. Amsterdam: Elsevier B.V., v. 27, n. 4, p. 300-302, 2006.
ISSN 0924-8579 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 300-302
Fonte http://dx.doi.org/10.1016/j.ijantimicag.2005.11.008
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000237744800006
Endereço permanente http://repositorio.unifesp.br/handle/11600/28816

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