Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents

Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents

Autor Stefani, Helio A. Google Scholar
Oliveira, Carlindo B. Google Scholar
Almeida, Roberta B. Google Scholar
Pereira, Claudio M. P. Google Scholar
Braga, Rodolpho C. Google Scholar
Cella, Rodrigo Google Scholar
Borges, Vanessa C. Google Scholar
Savegnago, Lucielli Google Scholar
Nogueira, Cristina W. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Sergipe (UFS)
Resumo An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence of NH4Cl, in good yields and short reaction time. Some of the synthesized compounds were tested in vitro for their antioxidant activity. All of the selected compounds showed some antioxidant activity. Analogues compounds 3b and 4b exhibited a strong activity against lipid peroxidation induced by Fe + EDTA, while compounds 3b and 3d were the most potent in reducing ROS levels. (c) 2006 Elsevier SAS. All rights reserved.
Palavra-chave Biginelli
dihydropyrimidinones
antioxidant
reactive oxygen species
pharmacological
Idioma Inglês
Data de publicação 2006-04-01
Publicado em European Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 41, n. 4, p. 513-518, 2006.
ISSN 0223-5234 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 513-518
Fonte http://dx.doi.org/10.1016/j.ejmech.2006.01.007
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000238054100009
Endereço permanente http://repositorio.unifesp.br/handle/11600/28814

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta