Myocardial dysfunction in mitochondrial diabetes treated with coenzyme Q10

Myocardial dysfunction in mitochondrial diabetes treated with coenzyme Q10

Autor Salles, J. E. Google Scholar
Moises, V. A. Google Scholar
Almeida, D. R. Google Scholar
Chacra, A. R. Google Scholar
Moises, R. S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Maternally-inherited diabetes and deafness (MIDD) has been related to an A to G transition in the mitochondrial tRNA Leu (UUR) gene at the base pair 3243. Although some previous articles have reported that this mutation may be a cause of cardiomyopathy in diabetes, the degree of cardiac involvement and a specific treatment has not been established. Here, we reported a case of a patient with MIDD who developed congestive heart failure and the therapeutic usefulness of Coenzyme Q10 (CoQ10). in our patient, after the introduction of Coenzyme Q10 150 mg/day, there was a gradual improvement on left ventricular function evaluated by echocardiography. the fractional shortening (FS) and ejection fraction (EF) increased from 26 to 34% and from 49 to 64%, respectively. No side effects were noted. Three months after CoQ10 discontinuation, the parameters of systolic function evaluated by echocardiography decreased, suggesting that CoQ10 had a beneficial effect. Identification of diabetes and cardiomyopathy due to mitochondrial gene mutation may have therapeutic implications and Coenzyme Q10 is a possible adjunctive treatment in such patients. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave mitochondrial tRNA Leu (UUR) gene
cardiomyopathy
coenzyme Q10
diabetes mellitus
Idioma Inglês
Data de publicação 2006-04-01
Publicado em Diabetes Research and Clinical Practice. Clare: Elsevier B.V., v. 72, n. 1, p. 100-103, 2006.
ISSN 0168-8227 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 100-103
Fonte http://dx.doi.org/10.1016/j.diabres.2005.09.005
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000237094100016
Endereço permanente http://repositorio.unifesp.br/handle/11600/28813

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