Distinct kinetics of effector CD8(+) cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice

Distinct kinetics of effector CD8(+) cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice

Author Tzelepis, Fanny Autor UNIFESP Google Scholar
Alencar, Bruna CG de Autor UNIFESP Google Scholar
Penido, Marcus LO Google Scholar
Gazzinelli, Ricardo T. Google Scholar
Persechini, Pedro M. Google Scholar
Rodrigues, Mauricio M. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fiocruz MS
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract The kinetics of effector CD8(+)-T-cell responses to specific Trypanosoma cruzi epitopes was investigated after challenge. Our results suggest that the delayed kinetics differs from that observed in other microbial infections and facilitates the establishment of the disease in naive mice. in contrast, in vaccinated mice, the swift CD8(+)-T-cell response helps host survival after challenge.
Language English
Date 2006-04-01
Published in Infection and Immunity. Washington: Amer Soc Microbiology, v. 74, n. 4, p. 2477-2481, 2006.
ISSN 0019-9567 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 2477-2481
Origin http://dx.doi.org/10.1128/IAI.74.4.2477-2481.2006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000236477000056
URI http://repositorio.unifesp.br/handle/11600/28804

Show full item record




File

Name: WOS000236477000056.pdf
Size: 136.2Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account