Distinct kinetics of effector CD8(+) cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice

Distinct kinetics of effector CD8(+) cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice

Autor Tzelepis, Fanny Autor UNIFESP Google Scholar
Alencar, Bruna CG de Autor UNIFESP Google Scholar
Penido, Marcus LO Google Scholar
Gazzinelli, Ricardo T. Google Scholar
Persechini, Pedro M. Google Scholar
Rodrigues, Mauricio M. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Fiocruz MS
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal do Rio de Janeiro (UFRJ)
Resumo The kinetics of effector CD8(+)-T-cell responses to specific Trypanosoma cruzi epitopes was investigated after challenge. Our results suggest that the delayed kinetics differs from that observed in other microbial infections and facilitates the establishment of the disease in naive mice. in contrast, in vaccinated mice, the swift CD8(+)-T-cell response helps host survival after challenge.
Idioma Inglês
Data 2006-04-01
Publicado em Infection and Immunity. Washington: Amer Soc Microbiology, v. 74, n. 4, p. 2477-2481, 2006.
ISSN 0019-9567 (Sherpa/Romeo, fator de impacto)
Editor Amer Soc Microbiology
Extensão 2477-2481
Fonte http://dx.doi.org/10.1128/IAI.74.4.2477-2481.2006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000236477000056
URI http://repositorio.unifesp.br/handle/11600/28804

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