Retinal nerve fibre layer thickness profile in normal eyes using third-generation optical coherence tomography

Retinal nerve fibre layer thickness profile in normal eyes using third-generation optical coherence tomography

Autor Autor UNIFESP Google Scholar
Bernardes, A. B. Google Scholar
Cardillo, J. A. Google Scholar
Costa, R. A. Google Scholar
Melo, Luiz Alberto Soares Autor UNIFESP Google Scholar
Castro, J. C. Google Scholar
Varma, R. Google Scholar
Instituição Hosp Olhos Araraquara
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ So Calif
Resumo Aims To establish four normal retinal nerve fibre layer (RNFL) thickness radial profiles based on third-generation optical coherence tomography (OCT) and to compare them with previously reported histologic measurements.Methods A total of 20 normal eyes were studied. A circular scan was adjusted to the size of the optic disc and three scans were performed with this radius and every 200 mu m thereafter, up to a distance of 1400 mu m. Four different radial sections (superotemporal, superonasal, inferonasal, and inferotemporal) were studied to establish RNFL thickness OCT profiles. Additionally, two radial scans orientated at 45 and 1351 crossing the optic disc centre were performed in six of 20 eyes, and RNFL thickness was measured at disc margin.Results Quadrant location and distance from disc margin interaction in RNFL thickness was statistically significant (P < 0.001). the RNFL thickness decreased (P < 0.001) as the distance from the disc margin increased for all sections. the measurements automatically generated by the OCT built-in software were thinner (P < 0.001) than histologic ones close to the disc margin.Conclusions Four normal OCT RNFL profiles were established and compared with histological data obtained from the same area. RNFL measurements assessed by OCT 3 were significantly thinner close to the optic disc margin.
Idioma Inglês
Data de publicação 2006-04-01
Publicado em Eye. London: Nature Publishing Group, v. 20, n. 4, p. 431-439, 2006.
ISSN 0950-222X (Sherpa/Romeo, fator de impacto)
Publicador Nature Publishing Group
Extensão 431-439
Fonte http://dx.doi.org/10.1038/sj.eye.6701896
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000236561100006
Endereço permanente http://repositorio.unifesp.br/handle/11600/28798

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