Corneal endothelial cell morphology of normal dogs in different ages

Corneal endothelial cell morphology of normal dogs in different ages

Autor Rodrigues, G. N. Google Scholar
Laus, J. L. Google Scholar
Santos, J. M. Google Scholar
Rigueiro, M. P. Google Scholar
Smith, R. L. Google Scholar
Instituição UNESP
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Endothelial cell function is essential to maintain corneal transparency, but unfortunately the regenerative capacity of the endothelium is limited. There are only a few reports describing the effect of age on morphologic appearance of corneal endothelial cells of dogs. Studies of normal corneal endothelial cells in humans and dogs have shown a decrease in endothelial cell density (ECD) and an increase in pleomorphism and polymegethism with advancing age. the purpose of this study was to investigate the effect of age on ECD and endothelial cell morphology in dogs. A total of 30 dogs were divided into three groups (10 dogs/group) based on age: group 1 (2-12 months old), group 2 (24-72 months old), and group 3 (84 months or older). Corneas were processed for light and scanning electron microscopy. Results showed only difference in cell density between group 1 and groups 2 and 3, showing an initial decrease in cell density as the animal matured. Whereas there was significantly greater variation in cell size within the dogs in group 3 than there was within the other two groups, suggesting that there was increased polymegethism and pleomorphism with advancing age.
Palavra-chave corneal endothelium
dog
morphology
morphometry
scanning electron microscopy
Idioma Inglês
Data de publicação 2006-03-01
Publicado em Veterinary Ophthalmology. Oxford: Blackwell Publishing, v. 9, n. 2, p. 101-107, 2006.
ISSN 1463-5216 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 101-107
Fonte http://dx.doi.org/10.1111/j.1463-5224.2006.00427.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235416500005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28785

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