p53 and skin carcinomas with skull base invasion: A case-control study

p53 and skin carcinomas with skull base invasion: A case-control study

Autor Cernea, C. R. Google Scholar
Ferraz, A. R. Google Scholar
Castro, IV de Google Scholar
Sotto, M. N. Google Scholar
Logullo, A. F. Google Scholar
Bacchi, C. E. Google Scholar
Potenza, A. S. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Albert Einstein Jewish Hosp
Resumo BACKGROUND: Some skill carcinomas may be very aggressive. Increased expression of the protein p53 has been associated with tumor aggressiveness. in this study, p53 expression was evaluated in basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) with skull base invasion, and was compared to tumors with good outcome.STUDY DESIGN and SETTING: Expression of p53 was immunohistochemically analyzed and it was reported as present or absent in 24 BCC and 11 SCC with skull base invasion. Control,group (good Outcome) included 23 BCC and 10 SCC.RESULTS: Expression of p53 was noted in 70.83% of BCC with skull base invasion, compared to 43.48% in the control group (P = 0.058). Regarding SCC, p53 positivity was noted in only 9.09% of SCC with skull base invasion, compared to 40.00% in the control group (P = 0. 149).CONCLUSIONS: in this study, p53 expression was more common among BCC with skull base invasion, compared to controls with good outcome, and the difference was considered marginally significant. This proportion was reversed in SCC, but the difference was not statistically significant.
Idioma Inglês
Data de publicação 2006-03-01
Publicado em Otolaryngology-head and Neck Surgery. St Louis: Mosby, Inc, v. 134, n. 3, p. 471-475, 2006.
ISSN 0194-5998 (Sherpa/Romeo, fator de impacto)
Publicador Mosby, Inc
Extensão 471-475
Fonte http://dx.doi.org/10.1016/j.otohns.2005.10.030
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235896400021
Endereço permanente http://repositorio.unifesp.br/handle/11600/28776

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