Cytotoxic and genotoxic monitoring of sickle cell anaemia patients treated with hydroxyurea

Cytotoxic and genotoxic monitoring of sickle cell anaemia patients treated with hydroxyurea

Autor Khayat, A. S. Google Scholar
Antunes, L. M. Google Scholar
Guimaraes, A. C. Google Scholar
Bahia, M. O. Google Scholar
Lemos, JAR Google Scholar
Cabral, I. R. Google Scholar
Lima, PDL Google Scholar
Amorim, MIM Google Scholar
Cardoso, PCS Google Scholar
Smith, MAC Google Scholar
Santos, R. A. Google Scholar
Burbano, R. R. Google Scholar
Instituição Fed Univ Para
Fac med Triangulo Mineiro
Ctr Hemoterapia & Hematol Estado Para
Univ Amazonia
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Very satisfactory results have been obtained with the treatment of sickle cell anaemia with hydroxyurea (HU), an antineoplastic drug. This is because it significantly increases the levels of foetal haemoglobin. Nevertheless, inadequate dosages or prolonged treatment with this pharmaceutical can provoke cytotoxicity or genotoxicity, increasing the risk of neoplasia. We monitored patients under treatment with HU for possible mutagenic effects, through cytogenetic tests (mitotic index and chromosome aberrations) for one year. Checking at two-month intervals, the cytotoxic effect was not evident. There was no evidence of genotoxicity under the conditions of our experiment. However individuals treated with HU should be constantly monitored, as an absence of genotoxicity could be transitory; the mitotic index should also be observed, as an indicator of cytotoxicity.
Assunto hydroxyurea
sickle cell anaemia
foetal haemoglobin
genotoxic monitoring
Idioma Inglês
Data 2006-03-01
Publicado em Clinical and Experimental Medicine. New York: Springer, v. 6, n. 1, p. 33-37, 2006.
ISSN 1591-8890 (Sherpa/Romeo, fator de impacto)
Editor Springer
Extensão 33-37
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000236147200005

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