Dysmorphic neurons in patients with temporal lobe epilepsy

Dysmorphic neurons in patients with temporal lobe epilepsy

Autor Silva, A. V. da Google Scholar
Houzel, J. C. Google Scholar
Yacubian, EMT Google Scholar
Carrete, H. Google Scholar
Sakamoto, A. C. Google Scholar
Priel, M. R. Google Scholar
Martins, H. H. Google Scholar
Oliveira, I Google Scholar
Garzon, E. Google Scholar
Stavale, J. N. Google Scholar
Centeno, R. D. Google Scholar
Machado, H. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade de São Paulo (USP)
Resumo We studied morphologic characteristics of dysmorphic neurons in the hippocampus of seven patients with medically intractable TLE and compare histological, clinical, and imaging features with ten TLE patients with classical hippocampal sclerosis without abnormal cells. Such dysmorphic neurons were observed in the hilus of the dentate gyrus and were characterized by giant or misshapen cells with abnormal cytoskeletal structure and atypical dendritic processes that resembled the dysmorphic neurons from cortical dysplasias. Specimens with dysmorphic cells also contained other cyto architectural abnormalities including bilamination of the clentate granular cell layer (four out seven cases), and the presence of Cajal-Retzius cells in the dentate gyrus or Ammon's horn (five out seven cases). There were no statistically significant differences regarding the age at onset, duration of epilepsy, and hippocampal asymmetry ratio between patients with or without dysmorphic cells. Nevertheless, it is interesting to note that a higher proportion of patients with dysmorphic neurons continued to present auras after surgery, when compared with patients without those cells. (c) 2005 Elsevier B.V. All rights reserved.
Palavra-chave epilepsy
malformation
dysmorphic neuron
TLE
immunocytochemistry
Idioma Inglês
Data de publicação 2006-02-09
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 1072, n. 1, p. 200-207, 2006.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 200-207
Fonte http://dx.doi.org/10.1016/j.brainres.2005.10.088
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000236051900023
Endereço permanente http://repositorio.unifesp.br/handle/11600/28744

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