Genetically altered animal models in the kallikrein-kinin system

Show simple item record Pesquero, J. B. Bader, M. 2016-01-24T12:40:59Z 2016-01-24T12:40:59Z 2006-02-01
dc.identifier.citation Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 387, n. 2, p. 119-126, 2006.
dc.identifier.issn 1431-6730
dc.description.abstract Transgenic and gene-targeting technologies allowing the generation of genetically altered animal models have greatly advanced our understanding of the function of specific genes. This is also true for the kallikrein-kinin system (KKS), in which some, but not yet all, components have been functionally characterized using such techniques. the first genetically altered animal model for a KKS component was supplied by nature, the brown Norway rat carrying an inactivating mutation in the kininogen gene. Mice deficient in tissue kallikrein, B1 and B2 receptors, some kinin-degrading enzymes, and factor XII followed, together with transgenic rat and mouse strains overexpressing tissue kallikrein, B1 and B2 receptors, and degrading enzymes. There are still no animal models with genetic alterations in plasma kallikrein, kininases I and some other degrading enzymes. the models have confirmed an important role of the KKS in cardiovascular pathology, inflammation, and pain, and have partially elucidated the distinct function of the two receptors. This created the basis for rational decisions concerning the putative use of kinin receptor agonists and antagonists in therapeutic applications. However, a more thorough analysis of the existing models and the generation of new, more sophisticated transgenic models will be necessary to clarify the still elusive issue as to where and by which mechanisms the kinins exert their actions. en
dc.format.extent 119-126
dc.language.iso eng
dc.publisher Walter de Gruyter & Co
dc.relation.ispartof Biological Chemistry
dc.rights Acesso restrito
dc.subject bradykinin en
dc.subject kininase en
dc.subject kininogen en
dc.subject kinin receptor en
dc.subject knockout animals en
dc.subject transgenic animals en
dc.title Genetically altered animal models in the kallikrein-kinin system en
dc.type Artigo
dc.contributor.institution Max Delbruck Ctr Mol Med
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany
dc.description.affiliation Universidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biophys, BR-04023062 São Paulo, Brazil
dc.identifier.doi 10.1515/BC.2006.017
dc.description.source Web of Science
dc.identifier.wos WOS:000235777400002


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