Genetically altered animal models in the kallikrein-kinin system

Genetically altered animal models in the kallikrein-kinin system

Author Pesquero, J. B. Google Scholar
Bader, M. Google Scholar
Institution Max Delbruck Ctr Mol Med
Universidade Federal de São Paulo (UNIFESP)
Abstract Transgenic and gene-targeting technologies allowing the generation of genetically altered animal models have greatly advanced our understanding of the function of specific genes. This is also true for the kallikrein-kinin system (KKS), in which some, but not yet all, components have been functionally characterized using such techniques. the first genetically altered animal model for a KKS component was supplied by nature, the brown Norway rat carrying an inactivating mutation in the kininogen gene. Mice deficient in tissue kallikrein, B1 and B2 receptors, some kinin-degrading enzymes, and factor XII followed, together with transgenic rat and mouse strains overexpressing tissue kallikrein, B1 and B2 receptors, and degrading enzymes. There are still no animal models with genetic alterations in plasma kallikrein, kininases I and some other degrading enzymes. the models have confirmed an important role of the KKS in cardiovascular pathology, inflammation, and pain, and have partially elucidated the distinct function of the two receptors. This created the basis for rational decisions concerning the putative use of kinin receptor agonists and antagonists in therapeutic applications. However, a more thorough analysis of the existing models and the generation of new, more sophisticated transgenic models will be necessary to clarify the still elusive issue as to where and by which mechanisms the kinins exert their actions.
Keywords bradykinin
kininase
kininogen
kinin receptor
knockout animals
transgenic animals
Language English
Date 2006-02-01
Published in Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 387, n. 2, p. 119-126, 2006.
ISSN 1431-6730 (Sherpa/Romeo, impact factor)
Publisher Walter de Gruyter & Co
Extent 119-126
Origin http://dx.doi.org/10.1515/BC.2006.017
Access rights Closed access
Type Article
Web of Science ID WOS:000235777400002
URI http://repositorio.unifesp.br/handle/11600/28742

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account