Genetically altered animal models in the kallikrein-kinin system

Genetically altered animal models in the kallikrein-kinin system

Autor Pesquero, J. B. Google Scholar
Bader, M. Google Scholar
Instituição Max Delbruck Ctr Mol Med
Universidade Federal de São Paulo (UNIFESP)
Resumo Transgenic and gene-targeting technologies allowing the generation of genetically altered animal models have greatly advanced our understanding of the function of specific genes. This is also true for the kallikrein-kinin system (KKS), in which some, but not yet all, components have been functionally characterized using such techniques. the first genetically altered animal model for a KKS component was supplied by nature, the brown Norway rat carrying an inactivating mutation in the kininogen gene. Mice deficient in tissue kallikrein, B1 and B2 receptors, some kinin-degrading enzymes, and factor XII followed, together with transgenic rat and mouse strains overexpressing tissue kallikrein, B1 and B2 receptors, and degrading enzymes. There are still no animal models with genetic alterations in plasma kallikrein, kininases I and some other degrading enzymes. the models have confirmed an important role of the KKS in cardiovascular pathology, inflammation, and pain, and have partially elucidated the distinct function of the two receptors. This created the basis for rational decisions concerning the putative use of kinin receptor agonists and antagonists in therapeutic applications. However, a more thorough analysis of the existing models and the generation of new, more sophisticated transgenic models will be necessary to clarify the still elusive issue as to where and by which mechanisms the kinins exert their actions.
Palavra-chave bradykinin
kininase
kininogen
kinin receptor
knockout animals
transgenic animals
Idioma Inglês
Data de publicação 2006-02-01
Publicado em Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 387, n. 2, p. 119-126, 2006.
ISSN 1431-6730 (Sherpa/Romeo, fator de impacto)
Publicador Walter de Gruyter & Co
Extensão 119-126
Fonte http://dx.doi.org/10.1515/BC.2006.017
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235777400002
Endereço permanente http://repositorio.unifesp.br/handle/11600/28742

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