Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome

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dc.contributor.author Arkader, R.
dc.contributor.author Troster, E. J.
dc.contributor.author Lopes, M. R.
dc.contributor.author Junior, R. R.
dc.contributor.author Carcillo, J. A.
dc.contributor.author Leone, C.
dc.contributor.author Okay, T. S.
dc.date.accessioned 2016-01-24T12:40:58Z
dc.date.available 2016-01-24T12:40:58Z
dc.date.issued 2006-02-01
dc.identifier http://dx.doi.org/10.1136/adc.2005.077446
dc.identifier.citation Archives of Disease in Childhood. London: B M J Publishing Group, v. 91, n. 2, p. 117-120, 2006.
dc.identifier.issn 0003-9888
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28740
dc.description.abstract Aims: To evaluate whether procalcitonin ( PCT) and C reactive protein (CRP) are able to discriminate between sepsis and systemic inflammatory response syndrome ( SIRS) in critically ill children.Methods: Prospective, observational study in a paediatric intensive care unit. Kinetics of PCT and CRP were studied in patients undergoing open heart surgery with cardiopulmonary bypass (CPB) ( SIRS model; group I-1) and patients with confirmed bacterial sepsis ( group II).Results: in group I, PCT median concentration was 0.24 ng/ml ( reference value <2.0 ng/ml). There was an increment of PCT concentrations which peaked immediately after CPB ( median 0.58 ng/ml), then decreased to 0.47 ng/ml at 24 h; 0.33 ng/ml at 48 h, and 0.22 ng/ml at 72 h. CRP median concentrations remained high on POD1 (36.6 mg/l) and POD2 (13.0 mg/l). in group II, PCT concentrations were high at admission ( median 9.15 ng/ml) and subsequently decreased in 11/14 patients who progressed favourably ( median 0.31 ng/ml). CRP levels were high in only 11/14 patients at admission. CRP remained high in 13/14 patients at 24 h; in 12/14 at 48 h; and in 10/14 patients at 72 h. Median values were 95.0, 50.9, 86.0, and 20.3 mg/l, respectively. the area under the ROC curve was 0.99 for PCT and 0.54 for CRP. Cut off concentrations to differentiate SIRS from sepsis were >2 ng/ ml for PCT and >79 mg/l for CRP.Conclusion: PCT is able to differentiate between SIRS and sepsis while CRP is not. Moreover, unlike CRP, PCT concentrations varied with the evolution of sepsis. en
dc.format.extent 117-120
dc.language.iso eng
dc.publisher B M J Publishing Group
dc.relation.ispartof Archives of Disease in Childhood
dc.rights Acesso restrito
dc.title Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Univ Pittsburgh
dc.description.affiliation Univ São Paulo, Fac Med, Dept Pediat, Lab Invest Med LIM36, BR-05403900 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Hosp Clin, Inst Crianca,Pediat Intens Care Unit, BR-05508 São Paulo, Brazil
dc.description.affiliation Hosp Clin São Paulo, Inst Crianca, Nucleo Consultoria & Apoio Metodol Pesquisa & Est, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Hosp Clin, Inst Coracao,Dept Anestesiol, BR-05508 São Paulo, Brazil
dc.description.affiliation Univ Pittsburgh, Sch Med, Childrens Hosp Pittsburgh, Dept Crit Care Med, Pittsburgh, PA USA
dc.identifier.doi 10.1136/adc.2005.077446
dc.description.source Web of Science
dc.identifier.wos WOS:000234760100010



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