Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome

Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome

Autor Arkader, R. Google Scholar
Troster, E. J. Google Scholar
Lopes, M. R. Google Scholar
Junior, R. R. Google Scholar
Carcillo, J. A. Google Scholar
Leone, C. Google Scholar
Okay, T. S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Pittsburgh
Resumo Aims: To evaluate whether procalcitonin ( PCT) and C reactive protein (CRP) are able to discriminate between sepsis and systemic inflammatory response syndrome ( SIRS) in critically ill children.Methods: Prospective, observational study in a paediatric intensive care unit. Kinetics of PCT and CRP were studied in patients undergoing open heart surgery with cardiopulmonary bypass (CPB) ( SIRS model; group I-1) and patients with confirmed bacterial sepsis ( group II).Results: in group I, PCT median concentration was 0.24 ng/ml ( reference value <2.0 ng/ml). There was an increment of PCT concentrations which peaked immediately after CPB ( median 0.58 ng/ml), then decreased to 0.47 ng/ml at 24 h; 0.33 ng/ml at 48 h, and 0.22 ng/ml at 72 h. CRP median concentrations remained high on POD1 (36.6 mg/l) and POD2 (13.0 mg/l). in group II, PCT concentrations were high at admission ( median 9.15 ng/ml) and subsequently decreased in 11/14 patients who progressed favourably ( median 0.31 ng/ml). CRP levels were high in only 11/14 patients at admission. CRP remained high in 13/14 patients at 24 h; in 12/14 at 48 h; and in 10/14 patients at 72 h. Median values were 95.0, 50.9, 86.0, and 20.3 mg/l, respectively. the area under the ROC curve was 0.99 for PCT and 0.54 for CRP. Cut off concentrations to differentiate SIRS from sepsis were >2 ng/ ml for PCT and >79 mg/l for CRP.Conclusion: PCT is able to differentiate between SIRS and sepsis while CRP is not. Moreover, unlike CRP, PCT concentrations varied with the evolution of sepsis.
Idioma Inglês
Data de publicação 2006-02-01
Publicado em Archives of Disease in Childhood. London: B M J Publishing Group, v. 91, n. 2, p. 117-120, 2006.
ISSN 0003-9888 (Sherpa/Romeo, fator de impacto)
Publicador B M J Publishing Group
Extensão 117-120
Fonte http://dx.doi.org/10.1136/adc.2005.077446
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234760100010
Endereço permanente http://repositorio.unifesp.br/handle/11600/28740

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