Cytokine genotyping in preeclampsia

Cytokine genotyping in preeclampsia

Autor Daher, S. Google Scholar
Sass, N. Google Scholar
Oliveira, L. G. Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo ProblemConsidering that cytokines are involved in preeclampsia (PE) pathogenesis and that cytokine gene polymorphism may affect cytokine production, our purpose was to investigate the association of PE with tumor necrosis factor (TNF)-alpha (-308), transforming growth factor-beta 1 (+10; 25), interleukin (IL)-10 (-1082), IL-6 (-174), and interferon-gamma (+874) polymorphisms.Method of studyGenotyping was performed in women with PE (56 White and 95 non-White women) and in women without obstetric pathology (92 White and 97 non-White women). Data were analyzed by the chi-square or Fisher exact test. We performed a meta-analysis encompassing these and results from other laboratories on the association of TNF-alpha polymorphisms and PE.ResultsWe observed a lower frequency of the IL-10 -1082-G/G genotype in White women with PE (PE: 5%; Control (C): 15%, P = 0.02) and no association for all other polymorphisms, including meta-analysis of TNF-alpha results.ConclusionOur study suggests that PE is associated with IL-10-(1082) polymorphism but not with TNF-(308) polymorphism. On the basis of meta-analysis, we confirm the need for more studies for the evaluation of cytokine genotype in disease.
Palavra-chave Cytokine
gene polymorphism
Idioma Inglês
Data de publicação 2006-02-01
Publicado em American Journal of Reproductive Immunology. Oxford: Blackwell Publishing, v. 55, n. 2, p. 130-135, 2006.
ISSN 1046-7408 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 130-135
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234794500006
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