Panniculitis in childhood and adolescence

Show simple item record Moraes, AJP Soares, PMF Zapata, A. L. Lotito, A. P. Sallum, A. M. Silva, CAA 2016-01-24T12:40:58Z 2016-01-24T12:40:58Z 2006-02-01
dc.identifier.citation Pediatrics International. Oxford: Blackwell Publishing, v. 48, n. 1, p. 48-53, 2006.
dc.identifier.issn 1328-8067
dc.description.abstract Background: the purpose of the present paper was to describe the clinical manifestations and treatment of patients with panniculitis.Methods: From January 1983 to December 2002, 4294 patients were treated for pediatric rheumatological diseases at Pediatric Rheumatology Unit, University of São Paulo, Brazil. of these, 35 children and adolescents (0.8%) presented with panniculitis: erythema nodosum (EN) or Weber-Christian disease (WCD). Clinical characteristics, laboratory exams, biopsy of the lesion, treatment and clinical course were studied.Results: of the 35 patients, 29 presented with EN and six with WCD, one of these with cytophagic histiocytic panniculitis. Mean age at symptom onset was 85 months (6-204 months) and the mean duration of follow up was 55 months (1-144 months). All the patients presented with inflammatory subcutaneous nodules. the patients with WCD presented with systemic manifestations and cutaneous atrophy. the principal etiologies of EN were streptococcal infection (42%), undetermined (13.5%), pulmonary tuberculosis (10%), and acute rheumatic fever (10%). Biopsy of the nodules indicated septal panniculitis in 14 patients with EN and lobular panniculitis without vasculitis in the patients with WCD, one of which had cytophagic histiocytic panniculitis. There was recurrence in 11 patients (38%) with EN and in all those with WCD. Non-steroidal anti-inflammatory drugs were used in 15 patients with EN and corticosteroids and/or immunosuppressive drugs in the six patients with WCD. Three patients died.Conclusion: EN is the most frequent panniculitis, with a benign course and is mainly associated with infections. WCD is a severe disease, with systemic involvement, that proceeds with cutaneous atrophy and requires the use of corticosteroids and or immunosuppressive drugs. en
dc.format.extent 48-53
dc.language.iso eng
dc.publisher Blackwell Publishing
dc.relation.ispartof Pediatrics International
dc.rights Acesso restrito
dc.subject children en
dc.subject erythema nodosum en
dc.subject panniculitis en
dc.subject Weber-Christian disease en
dc.title Panniculitis in childhood and adolescence en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Dept Pediat, Pediat Rheumatol Unit, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1442-200X.2006.02169.x
dc.description.source Web of Science
dc.identifier.wos WOS:000235418300010


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