Panniculitis in childhood and adolescence

Panniculitis in childhood and adolescence

Autor Moraes, AJP Google Scholar
Soares, PMF Google Scholar
Zapata, A. L. Google Scholar
Lotito, A. P. Google Scholar
Sallum, A. M. Google Scholar
Silva, CAA Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: the purpose of the present paper was to describe the clinical manifestations and treatment of patients with panniculitis.Methods: From January 1983 to December 2002, 4294 patients were treated for pediatric rheumatological diseases at Pediatric Rheumatology Unit, University of São Paulo, Brazil. of these, 35 children and adolescents (0.8%) presented with panniculitis: erythema nodosum (EN) or Weber-Christian disease (WCD). Clinical characteristics, laboratory exams, biopsy of the lesion, treatment and clinical course were studied.Results: of the 35 patients, 29 presented with EN and six with WCD, one of these with cytophagic histiocytic panniculitis. Mean age at symptom onset was 85 months (6-204 months) and the mean duration of follow up was 55 months (1-144 months). All the patients presented with inflammatory subcutaneous nodules. the patients with WCD presented with systemic manifestations and cutaneous atrophy. the principal etiologies of EN were streptococcal infection (42%), undetermined (13.5%), pulmonary tuberculosis (10%), and acute rheumatic fever (10%). Biopsy of the nodules indicated septal panniculitis in 14 patients with EN and lobular panniculitis without vasculitis in the patients with WCD, one of which had cytophagic histiocytic panniculitis. There was recurrence in 11 patients (38%) with EN and in all those with WCD. Non-steroidal anti-inflammatory drugs were used in 15 patients with EN and corticosteroids and/or immunosuppressive drugs in the six patients with WCD. Three patients died.Conclusion: EN is the most frequent panniculitis, with a benign course and is mainly associated with infections. WCD is a severe disease, with systemic involvement, that proceeds with cutaneous atrophy and requires the use of corticosteroids and or immunosuppressive drugs.
Palavra-chave children
erythema nodosum
panniculitis
Weber-Christian disease
Idioma Inglês
Data de publicação 2006-02-01
Publicado em Pediatrics International. Oxford: Blackwell Publishing, v. 48, n. 1, p. 48-53, 2006.
ISSN 1328-8067 (Sherpa/Romeo, fator de impacto)
Publicador Blackwell Publishing
Extensão 48-53
Fonte http://dx.doi.org/10.1111/j.1442-200X.2006.02169.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235418300010
Endereço permanente http://repositorio.unifesp.br/handle/11600/28737

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