Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection

Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection

Autor Moreno, Y. F. Google Scholar
Sgarbieri, V. C. Google Scholar
Silva, M. N. da Google Scholar
Toro, AADC Google Scholar
Vilela, MMS Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Resumo HIV infection is associated with subnormal GSH levels. An increase in glutathione levels has been observed in HIV-infected adults under oral whey protein supplementation. We studied the features associated with a whey protein concentrate supplementation in children with rapidly progressive AIDS. A prospective double-blind clinical trial was carried out for 4 months with 18 vertically HIV-infected children (1.98-6.37 years), under antiretroviral therapy, who had received whey protein, maltodextrin (placebo) or none. Erythrocyte glutathione concentration, T lymphocyte counts (CD4(+) and CD8(+)) and occurrence of associated co-infections were evaluated. Wilcoxon's and Fischer's Exact tests were used to assess differences between whey protein-supplemented and control (placebo and non-supplemented) groups. A significant median increase of 16.14 mg/dl (p = 0.018) in erythrocyte glutathione levels was observed in the whey protein-supplemented group; the TCD4/CD8 lymphocyte ratio showed a non significant increase and lower occurrence of associated co-infections was also observed. in conclusion, whey protein concentrate supplementation can stimulate glutathione synthesis and, possibly, decrease the occurrence of associated co-infections.
Idioma Inglês
Data de publicação 2006-02-01
Publicado em Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 52, n. 1, p. 34-38, 2006.
ISSN 0142-6338 (Sherpa/Romeo, fator de impacto)
Publicador Oxford Univ Press
Extensão 34-38
Fonte http://dx.doi.org/10.1093/tropej/fmi074
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234968100007
Endereço permanente http://repositorio.unifesp.br/handle/11600/28733

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