Quantitative imaging of Plasmodium transmission from mosquito to mammal

Quantitative imaging of Plasmodium transmission from mosquito to mammal

Autor Amino, R. Google Scholar
Thiberge, S. Google Scholar
Martin, B. Google Scholar
Celli, S. Google Scholar
Shorte, S. Google Scholar
Frischknecht, F. Google Scholar
Menard, R. Google Scholar
Instituição Inst Pasteur
Universidade Federal de São Paulo (UNIFESP)
Resumo Plasmodium, the parasite that causes malaria, is transmitted by a mosquito into the dermis and must reach the liver before infecting erythrocytes and causing disease. We present here a quantitative, real-time analysis of the fate of parasites transmitted in a rodent system. We show that only a proportion of the parasites enter blood capillaries, whereas others are drained by lymphatics. Lymph sporozoites stop at the proximal lymph node, where most are degraded inside dendritic leucocytes, but some can partially differentiate into exoerythrocytic stages. This previously unrecognized step of the parasite life cycle could influence the immune response of the host, and may have implications for vaccination strategies against the preerythrocytic stages of the parasite.
Idioma Inglês
Data de publicação 2006-02-01
Publicado em Nature Medicine. New York: Nature Publishing Group, v. 12, n. 2, p. 220-224, 2006.
ISSN 1078-8956 (Sherpa/Romeo, fator de impacto)
Publicador Nature Publishing Group
Extensão 220-224
Fonte http://dx.doi.org/10.1038/nm1350
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235160600027
Endereço permanente http://repositorio.unifesp.br/handle/11600/28729

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