The effect of experimental Bothrops jararaca envenomation on pregnant mice

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dc.contributor.author Spadacci-Morena, D. D.
dc.contributor.author Tomy, S. C. de
dc.contributor.author Sano-Martins, I. S.
dc.contributor.author Katz, S. G.
dc.date.accessioned 2016-01-24T12:40:57Z
dc.date.available 2016-01-24T12:40:57Z
dc.date.issued 2006-02-01
dc.identifier http://dx.doi.org/10.1016/j.toxicon.2005.10.016
dc.identifier.citation Toxicon. Oxford: Pergamon-Elsevier B.V., v. 47, n. 2, p. 196-207, 2006.
dc.identifier.issn 0041-0101
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28727
dc.description.abstract The injury caused by the intramuscular injection of a single dose of Bothrops jararaca venom (0.24 mg/kg body weight) to mice on day 8 of pregnancy and examined on day 9 was investigated. Macroscopic and histological examination showed that the bothropic venom caused an increase in the incidence of fetal resorptions. Histologically, a characteristic involution of mature decidua was noticed in saline-treated mice; however, necrotic trophoblast giant cells and decidual cells were also present in this region of mice treated with B. jararaca venom, mainly close to the embryo. Hemorrhagic areas were also observed at maternal-fetal interface, which contained maternal erythrocytes and polymorphonuclears. Plasma fibrinogen levels were lower in envenomed group (p <= 0.0001), but prothrombin time and activated partial thromboplastin time remained unaltered. Total and differential white blood cell counts were not statistically different between groups. Thus, B. jararaca venom causes injuries not only to the fetus, but also to decidual tissue and blood coagulation of pregnant mice. It is not clear, nonetheless, whether disturbances during the development of pregnancy are due to a direct effect of venom on uterus/fetus or to homeostatic changes in dams, such as clotting disturbances, or to both of them. (c) 2005 Elsevier B.V. All rights reserved. en
dc.format.extent 196-207
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Toxicon
dc.rights Acesso restrito
dc.subject Bothrops jararaca venom en
dc.subject fibrinogen en
dc.subject antimesometrial decidua en
dc.subject pregnancy en
dc.subject mice en
dc.title The effect of experimental Bothrops jararaca envenomation on pregnant mice en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Butantan Inst
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Butantan Inst, Lab Pathophysiol, BR-05503900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Dept Histol & Struct Biol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Dept Histol & Struct Biol, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.toxicon.2005.10.016
dc.description.source Web of Science
dc.identifier.wos WOS:000235798400009



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