Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling

Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling

Autor Lopes, Carla Cristina Autor UNIFESP Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a short cytoplasmic domain that binds cytosolic regulatory factors. the syndecans also contain highly conserved transmembrane domains and extracellular domains for which important activities are becoming known. These protein domains locate the syndecan on cell surface sites during development and tumor formation where they interact with other receptors to regulate signaling and cytoskeletal organization. the functions of cell surface heparan sulfate proteoglycan have been centered on the role of heparan sulfate chains, located on the outer side of the cell surface, in the binding of a wide array of ligands, including extracellular matrix proteins and soluble growth factors. More recently, the core proteins of the syndecan family transmembrane proteoglycans have also been shown to be involved in cell signaling through interaction with integrins and tyrosine kinase receptors.
Assunto syndecans
heparan sulfate proteoglycans
protein kinase C
growth factors
cell signaling
Idioma Inglês
Data 2006-02-01
Publicado em Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 39, n. 2, p. 157-167, 2006.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Editor Assoc Bras Divulg Cientifica
Extensão 157-167
Fonte http://dx.doi.org/10.1590/S0100-879X2006000200001
Direito de acesso Acesso aberto Open Access
Tipo Resenha
Web of Science WOS:000235452400001
SciELO S0100-879X2006000200001 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/28712

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