Influence of pinealectomy on the amygdala kindling development in rats

Influence of pinealectomy on the amygdala kindling development in rats

Author Janjoppi, L. Google Scholar
Lacerda, AFS de Google Scholar
Scorza, F. A. Google Scholar
Amado, D. Google Scholar
Cavalheiro, E. A. Google Scholar
Arida, R. M. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
UMC
Abstract A considerable number of studies have demonstrated the anticonvulsant effect of melatonin. the present study examines the influence of pinealectomy on the amygdala kindling development in rats. Animals were divided into three groups: Pinealectomized rats (PNT) Sham rats (SHAM) and Control rats (CTL). the mean number of stimulations and the afterdischarge (AD) duration for each stage of kindling were similar among CTL and SHAM animals. Conversely, PNT animals showed particular characteristics during kindling development. They did not present stage I and spent a shorter time in stage 2 in relation to the CTL and SHAM animals. Consequently, the number of stimulations required to reach stage 5 was lower for the PNT group when compared to the CTL and SHAM groups. Besides, a longer AD duration during stage 5 in the PNT group was also observed. the present findings indicate that the pineal gland removal exert a significant influence on amygdala kindling development suggesting that melatonin holds potential interest in experimental therapy for epilepsy. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
Keywords melatonin
pinealectomy
kindling
rat
epilepsy
Language English
Date 2006-01-09
Published in Neuroscience Letters. Clare: Elsevier B.V., v. 392, n. 1-2, p. 150-153, 2006.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 150-153
Origin http://dx.doi.org/10.1016/j.neulet.2005.09.009
Access rights Closed access
Type Article
Web of Science ID WOS:000234268400031
URI http://repositorio.unifesp.br/handle/11600/28689

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