Influence of pinealectomy on the amygdala kindling development in rats

Influence of pinealectomy on the amygdala kindling development in rats

Autor Janjoppi, L. Google Scholar
Lacerda, AFS de Google Scholar
Scorza, F. A. Google Scholar
Amado, D. Google Scholar
Cavalheiro, E. A. Google Scholar
Arida, R. M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UMC
Resumo A considerable number of studies have demonstrated the anticonvulsant effect of melatonin. the present study examines the influence of pinealectomy on the amygdala kindling development in rats. Animals were divided into three groups: Pinealectomized rats (PNT) Sham rats (SHAM) and Control rats (CTL). the mean number of stimulations and the afterdischarge (AD) duration for each stage of kindling were similar among CTL and SHAM animals. Conversely, PNT animals showed particular characteristics during kindling development. They did not present stage I and spent a shorter time in stage 2 in relation to the CTL and SHAM animals. Consequently, the number of stimulations required to reach stage 5 was lower for the PNT group when compared to the CTL and SHAM groups. Besides, a longer AD duration during stage 5 in the PNT group was also observed. the present findings indicate that the pineal gland removal exert a significant influence on amygdala kindling development suggesting that melatonin holds potential interest in experimental therapy for epilepsy. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
Palavra-chave melatonin
pinealectomy
kindling
rat
epilepsy
Idioma Inglês
Data de publicação 2006-01-09
Publicado em Neuroscience Letters. Clare: Elsevier B.V., v. 392, n. 1-2, p. 150-153, 2006.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 150-153
Fonte http://dx.doi.org/10.1016/j.neulet.2005.09.009
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234268400031
Endereço permanente http://repositorio.unifesp.br/handle/11600/28689

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