Screening for cervical cancer in high-risk populations: DNA pap test or Hybrid Capture II test alone?

Screening for cervical cancer in high-risk populations: DNA pap test or Hybrid Capture II test alone?

Autor Pereira, SMM Google Scholar
Castelo, A. Google Scholar
Makabe, S. Google Scholar
Utagawa, M. L. Google Scholar
Di Loreto, C. Google Scholar
Maeda, MYS Google Scholar
Marques, J. A. Google Scholar
Santoro, CLF Google Scholar
Longatto, A. Google Scholar
Das Dores, G. B. Google Scholar
Instituição Adolfo Lutz Inst
Universidade Federal de São Paulo (UNIFESP)
Perola Byignton Hosp
Univ Minho
Digene Brasil
Resumo This study was designed to evaluate whether Hybrid Capture II (HC2) test alone refer women to colposcopy as appropriately as DNA Papanicolaou (Pap) test, in the context of a high-risk group of women using the recently validated DNACitoliq (R) LBC system. Women with suspected cervical disease were included in this cross-sectional study at a tertiary center in São Paulo, Brazil, for further workup. All women had cervical material collected for LBC and HC2 for high-risk human papillomavirus (hrHPV)-DNA test. Irrespective of cytology and HC2 results, colposcopy, and cervical biopsy when applicable, was systematically performed. All tests were performed blindly. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of both methods were computed in relation to histology. A total of 1,080 women were included: 36.4% (393/1080) had ACUS+, 10.2% (110/1080) were high-grade squamous intraepithelial lesions (HSIL) or cancer. Mean age was 33.5 years. All women underwent colposcopy, and cervical biopsies were performed in 38.4% (415/1080): 33% (137/415) of the biopsies were negative, 14.4% (155/415) were low-grade squamous intraepithelial lesions (LSIL), 10.7% (116/415) were HSIL, and 0.6% (7/415) were cancer. HC2 sensitivity to diagnose biopsy-proven HSIL was 100%. Because all HSIL cases had a positive HC2 test, sensitivity could not be improved by adding LBC. Specificity and positive and negative predictive values of DNA Pap were not significantly different from HC2 test alone when considering LSIL+ histology as gold standard and HSIL+ histology. As a screening strategy for women with high-risk for cervical cancer, DNA Pap test does not seem to add substantially to HC2 alone in terms of appropriately referring to colposcopy.
Palavra-chave hybrid capture
DCS system
liquid-based cytology
Papanicolaou test
cervical cancer
cervical screening
Idioma Inglês
Data de publicação 2006-01-01
Publicado em International Journal of Gynecological Pathology. Philadelphia: Lippincott Williams & Wilkins, v. 25, n. 1, p. 38-41, 2006.
ISSN 0277-1691 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 38-41
Fonte http://dx.doi.org/10.1097/01.pgp.0000177122.71309.72
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234275600004
Endereço permanente http://repositorio.unifesp.br/handle/11600/28662

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