P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions

P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions

Autor Queiroz, C. Google Scholar
Silva, T. C. Google Scholar
Alves, VAF Google Scholar
Villa, L. L. Google Scholar
Costa, M. C. Google Scholar
Travassos, A. G. Google Scholar
Araujo, J. B. Google Scholar
Studart, E. Google Scholar
Cheto, T. Google Scholar
Freitas, LAR de Google Scholar
Instituição Universidade Federal da Bahia (UFBA)
Fiocruz MS
Universidade Federal de São Paulo (UNIFESP)
Ludwig Inst Canc Res
Resumo An immunohistochemical analysis with monoclonal antibody p16(INK4), was performed in formalin-fixed, paraffin-embedded samples of 60 cases. the aim was to investigate in biopsies the expression of p16(INK4a) of normal uterine cervical tissue, pre-cancerous and cancerous lesions, and their relation with human papilloma virus (HPV) and HIV status. Three parameters were evaluated: percentage of p16(INK4a) positive cells, reaction intensity, and cell staining pattern. All of these parameters were statistically different when compared among different histological groups. However, logistic regression model showed that the reaction intensity was the best indicator of the expression of p16(INK4a). This expression increases from normal to invasive squamous carcinoma. Sixty-six percent of the patients with CIN grade 1 (CIN1) expressed p16(INK4a) (all these cases were infected with high risk HPV). Our study supports the hypothesis that p16(INK4a) expression in pre-cancerous lesions and cancers can be used to identify HPV-transformed cells. of great interest for routine diagnostic use is the fact that immunohistochemical testing for p16(INK4a) seems to be capable of identifying HPV-positive cells and potentially recognizing those lesions with an increased risk of progression to high-grade lesions. (c) 2005 Elsevier GmbH. All rights reserved.
Palavra-chave cervical neoplasia
diagnostic marker
p16(INK4a)
human papillomavirus
human immunodeficiency virus
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Pathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 202, n. 2, p. 77-83, 2006.
ISSN 0344-0338 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 77-83
Fonte http://dx.doi.org/10.1016/j.prp.2005.08.012
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235606000003
Endereço permanente http://repositorio.unifesp.br/handle/11600/28652

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