TNF-alpha and IL-6 in the diagnosis of bacterial and aseptic meningitis in children

TNF-alpha and IL-6 in the diagnosis of bacterial and aseptic meningitis in children

Autor Mukai, A. O. Google Scholar
Krebs, VLJ Google Scholar
Bertoli, C. J. Google Scholar
Okay, T. S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Taubate Univ
Resumo The objective of this study was to analyze the usefulness of tumor necrosis factor-alpha and interleukin-6 cerebrospinal fluid concentrations for the differential diagnosis between bacterial and aseptic meningitis in children and in the prognostic evaluation. A crosssectional study was performed on 35 children between I month and 12 years of age with suspected meningitis. Cytokines determination was performed by enzyme-linked immunosorbent assay technique. the Mann-Whitney test and Spearman's correlation coefficients were used for statistical analysis. Six children presented bacterial meningitis, 13 aseptic, and 16 had no meningitis. the tumor necrosis factor-alpha concentrations were significantly higher in the bacterial meningitis group as compared with the aseptic group (P = 0.001) and among groups with and without meningitis (P = 0.000\). There was correlation between tumor necrosis factor-alpha and cerebrospinal fluid leukocytes (P = 0.019), protein (P = 0.000), and glucose (P = 0.038). There was no association between cytokines and complications of the meningitis. the tumor necrosis factor-alpha concentrations in the cerebrospinal fluid were useful markers for distinguishing bacterial from aseptic meningitis and were demonstrated to be useful in evaluating the intensity of the inflammatory process in the central nervous system. (c) 2006 by Elsevier Inc. All rights reserved.
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Pediatric Neurology. New York: Elsevier B.V., v. 34, n. 1, p. 25-29, 2006.
ISSN 0887-8994 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 25-29
Fonte http://dx.doi.org/10.1016/j.pediatrneurol.2005.06.003
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234660600005
Endereço permanente http://repositorio.unifesp.br/handle/11600/28651

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