In vitro activities of caspofungin, amphotericin B and azoles against Coccidioides posadasii strains from Northeast, Brazil

In vitro activities of caspofungin, amphotericin B and azoles against Coccidioides posadasii strains from Northeast, Brazil

Autor Cordeiro, R. A. Google Scholar
Brilhante, RSN Google Scholar
Rocha, MFG Google Scholar
Fechine, MAB Google Scholar
Costa, AKF Google Scholar
Camargo, Z. P. Google Scholar
Sidrim, JJC Google Scholar
Instituição Univ Fed Ceara
Univ Estadual Ceara
Universidade Federal de São Paulo (UNIFESP)
Resumo Coccidioidomycosis is a systemic infection caused by the soil-dwelling dimorphic fungi Coccidioides spp. the disease is endemic in semiarid Northeast Brazil, where it is caused by C. posadasii. the aim of this study was to perform antifungal susceptibility tests of clinical and environmental strains of C. posadasii from Northeast Brazil. the in vitro activities of caspofungin, amphotericin B and azoles against clinical and environment isolates of C. posadasii were determined in accordance with the NCLLS M-38P macrodilution method. the antifungal susceptibility analysis showed that all the strains of C. posadasii (n = 10) were sensitive to caspofungin (16 mu g/ml <= MIC <= 32 mu g/ml), amphotericin B (0.0625 mu g/ml <= MIC <= 0.125 mu g/ml), ketoconazole (0.039 mu g/ml <= MIC <= 0.156 mu g/ml), itraconazole (0.125 mu g/ml <= MIC <= 0.5 mu g/ml), fluconazole (3.125 mu g/ml <= MIC <= 6.25 mu g/ml), and voriconazole (0.125 mu g/ml). This study is the first description of in vitro antifungal susceptibility pattern of Brazilian strains of C. posadasii.
Palavra-chave antifungal susceptibility testing
Coccidioides posadasii
Northeast Brazil
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Mycopathologia. Dordrecht: Springer, v. 161, n. 1, p. 21-26, 2006.
ISSN 0301-486X (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 21-26
Fonte http://dx.doi.org/10.1007/s11046-005-0177-0
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234397000003
Endereço permanente http://repositorio.unifesp.br/handle/11600/28638

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