Effects of raloxifene on normal breast tissue from premenopausal women

Effects of raloxifene on normal breast tissue from premenopausal women

Autor Silva, B. B. da Google Scholar
Lopes, LMRS Google Scholar
Gebrim, L. H. Google Scholar
Instituição Fed Univ Piaui
Universidade Federal de São Paulo (UNIFESP)
Resumo The objective of this study was to evaluate the effects of raloxifene oil normal breast tissue. A randomized, doubleblind study was carried out in 30 ovulatory, premenopausal women of 18-40 years of age, who had been diagnosed with fibroadenoma of the breast. the patients were divided into two groups: Group A (placebo, n = 16) and Group B (raloxifene 60 mg, n= 14). the medication was given for 22 days, beginning on the first day of the menstrual cycle. An excisional biopsy was carried out on the 23rd day during which a sample of normal breast tissue was collected to evaluate the presence of the proliferating cell marker Ki-67. Student's /-test was used for the statistical analysis of data (p < 0.05). Mean percentage of stained nuclei in groups A and B was 10.96 +/- 1.27 and 1.21 +/- 0.26, respectively (p < 0.001). Raloxifene significantly reduced the proliferative activity of normal breast tissue in premenopausal women.
Palavra-chave breast
breast cancer chemoprevention
Ki-67
normal breast
raloxifene
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Breast Cancer Research and Treatment. New York: Springer, v. 95, n. 2, p. 99-103, 2006.
ISSN 0167-6806 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 99-103
Fonte http://dx.doi.org/10.1007/s10549-005-9001-2
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000236965100001
Endereço permanente http://repositorio.unifesp.br/handle/11600/28636

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