Fetal exposure to sodium valproate associated with Baller-Gerold syndrome: case report and review of the literature

Fetal exposure to sodium valproate associated with Baller-Gerold syndrome: case report and review of the literature

Autor Oliveira, R. S. de Google Scholar
Lajeunie, E. Google Scholar
Arnaud, E. Google Scholar
Renier, D. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Univ Paris 05
Resumo Case report: We report three patients with a history of maternal valproate use during pregnancy who presented with a combination of metopic suture synostosis and upper limb malformations, which could be diagnosed as Baller-Gerold syndrome (BGS). the patients underwent surgical treatment for the craniofacial deformity, during which standard frontocranial reconstruction was performed. Review of the literature: Only 32 patients have been reported in the world literature and these cases support the emerging view that BGS is not a distinct syndrome, but should instead be considered to be an heterogeneous phenotype with variable etiology. Conclusions: Our case series suggests for the first time that fetal sodium valproate exposure may also cause this phenotype.
Palavra-chave craniosynostosis
trigonocephaly
valproate syndrome
craniofacial surgery
cognitive development
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Childs Nervous System. New York: Springer, v. 22, n. 1, p. 90-94, 2006.
ISSN 0256-7040 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 90-94
Fonte http://dx.doi.org/10.1007/s00381-004-1089-x
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000234395600017
Endereço permanente http://repositorio.unifesp.br/handle/11600/28633

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