Fetal obstructive uropathy: is urine sampling useful for prenatal counselling?

Fetal obstructive uropathy: is urine sampling useful for prenatal counselling?

Autor Miguelez, J. Google Scholar
Bunduki, V Google Scholar
Yoshizaki, C. T. Google Scholar
Sadek, LDR Google Scholar
Koch, V Google Scholar
Peralta, CFA Google Scholar
Zugaib, M. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Objectives To evaluate whether fetal urinary sodium and chloride provide clinically useful information in addition to ultrasound in bilateral obstructive uropathy.Methods Sonographic features and urinary concentrations of sodium and chloride were evaluated in fetuses with bilateral obstructive uropathy. After a minimum of 12 months of postnatal follow-up, cases that developed increased serum creatinine (greater than 50 mu mol/L) were compared with those that did not.Results of the cases studied, 16/35 died perinatally, all showing anamnios and markedly elevated urinary electrolytes. of the survivors, ten maintained normal postnatal serum creatinine, whereas nine did not. the frequency of reduced amniotic fluid/olygohydramnios was higher in cases that developed increased serum creatinine (four out of nine) than in those that did not (nil). Sodium above the 95th percentile was 100% specific and 44% sensitive to predict an increased serum creatinine during early infancy, while chloride above the 95th percentile was 70% specific and 56% sensitive. All seven cases in which urinary sodium was elevated and/or amniotic fluid volume was reduced developed renal failure.Conclusion Urine sampling slightly improved renal function prediction, but this must be balanced against its fetal risks. Copyright (c) 2006 John Wiley & Sons, Ltd.
Palavra-chave prenatal diagnosis
ultrasound
bilateral obstructive uropathy
fetal urinalysis
sodium
chloride
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Prenatal Diagnosis. Chichester: John Wiley & Sons Ltd, v. 26, n. 1, p. 81-84, 2006.
ISSN 0197-3851 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 81-84
Fonte http://dx.doi.org/10.1002/pd.1360
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235173000017
Endereço permanente http://repositorio.unifesp.br/handle/11600/28626

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