Murine fetal small-intestine grafts: Morphometric and immunohistochemical evaluation

Murine fetal small-intestine grafts: Morphometric and immunohistochemical evaluation

Autor De Almeida, CES Google Scholar
De Oliveira, K. F. Google Scholar
Manna, MCB Google Scholar
Artigiani, R. Google Scholar
Koike, M. K. Google Scholar
Montero, EFD Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo We investigated histopathological changes following murine fetal intestinal transplantation. Fetal intestine, obtained from a pregnant C57BL/6 mouse, was transplanted into BALB/c and C57Bl/6 mice. Recipients were divided into three groups: isogeneic, and allogeneic treated with 3 mg/kg/day gangliosides (Allo-a) or 9 mg/kg/day (Allo-b). One week after transplant, all grafts showed good viability, confirmed by cellular mitosis in the mucosa and a well-defined propria muscular layer. Isogeneic grafts showed a thicker muscular layer than in the Allo-a (P = 0.02) and Allo-b (P = 0.004) groups. There was no dierence in number of mitotic cells among groups. Goblet cells were significantly reduced in allografts treated with 3 mg gangliosides (P = 0.013) or 9 mg gangliosides (P = 0.002) compared to isografts. Villi height was similar in all studied groups. There was no difference in positivity of the enteric nervous system among groups. Atrophy was more common in the allogeneic groups, suggesting that isografts had better development than allografts treated with gangliosides. (c) 2006 Wiley-Liss, Inc.
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Microsurgery. Hoboken: Wiley-liss, v. 26, n. 1, p. 61-64, 2006.
ISSN 0738-1085 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 61-64
Fonte http://dx.doi.org/10.1002/micr.20213
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000235199500014
Endereço permanente http://repositorio.unifesp.br/handle/11600/28624

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