Effect of GB virus C on response to antiretroviral therapy in HIV-infected Brazilians

Effect of GB virus C on response to antiretroviral therapy in HIV-infected Brazilians

Autor Souza, Inara Espinelli Lemes de Autor UNIFESP Google Scholar
Zhang, W. Google Scholar
Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Chaloner, K. Google Scholar
Klinzman, D. Google Scholar
Stapleton, J. T. Google Scholar
Instituição Univ Iowa
Iowa City Vet Adm
Universidade Federal de São Paulo (UNIFESP)
Resumo ObjectivesGB virus C (GBV-C) infection is associated with delayed mortality in HIV-infected people in most, but not all, studies. Previous investigations of the effect of GBV-C viraemia on response to antiretroviral therapy (ART) were inconclusive. To determine the effect of GBV-C on ART, we retrospectively analysed plasma samples taken from patients in a prospective randomized clinical trial of ART in HIV-positive Brazilians.MethodsGBV-C viraemia was characterized by testing stored serum samples from 175 participants by reverse transcriptase-polymerase chain reaction (RT-PCR). Subjects were randomized to receive indinavir (n=59), zidovudine and lamivudine (n=58), or zidovudine, lamivudine and indinavir (n=58). the effect of GBV-C viraemia on the average change in HIV viral load and CD4 count following initiation of therapy was evaluated in a multiple regression analysis.ResultsThe prevalence of GBV-C viraemia was similar to that observed in previous studies (24%). HIV viral load decreased following ART to a significantly greater extent in patients with GBV-C viraemia (by 0.48 log(10) HIV-1 RNA copies/mL, P=0.009, adjusting for age, ART group, and baseline CD4 count). Although there was no significant difference in change in CD4 count between individuals with and without GBV-C viraemia overall, CD4 counts were higher following 48 weeks of therapy in GBV-C viraemic individuals receiving the least potent ART regimen (zidovudine and lamivudine) compared with those without GBV-C infection.ConclusionsGBV-C viraemia is associated with an enhanced reduction of HIV viral load in response to ART. in this study of treatment-naive individuals during 48 weeks of follow up, patients with GBV-C viraemia had reductions in HIV viral load that were approximately 0.5 log copies/mL greater than those found in patients without GBV-C viraemia. This is similar to reductions observed with nucleoside reverse transcriptase inhibitors.
Assunto antiretroviral therapy
GB virus type C
hepatitis G
Idioma Inglês
Data 2006-01-01
Publicado em Hiv Medicine. Oxford: Blackwell Publishing, v. 7, n. 1, p. 25-31, 2006.
ISSN 1464-2662 (Sherpa/Romeo, fator de impacto)
Editor Blackwell Publishing
Extensão 25-31
Fonte http://dx.doi.org/10.1111/j.1468-1293.2005.00339.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000233623500004
URI http://repositorio.unifesp.br/handle/11600/28608

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