Cryptic speciation and recombination in the fungus Paracoccidioides brasiliensis as revealed by gene genealogies

Cryptic speciation and recombination in the fungus Paracoccidioides brasiliensis as revealed by gene genealogies

Autor Matute, D. R. Google Scholar
McEwen, J. G. Google Scholar
Puccia, Rosana Autor UNIFESP Google Scholar
San-Blas, G. Google Scholar
Bagagli, E. Google Scholar
Rauscher, J. T. Google Scholar
Restrepo, A. Google Scholar
Morais, Favia Autor UNIFESP Google Scholar
Nino-Vega, G. Google Scholar
Taylor, J. W. Google Scholar
Montes, B. A. Google Scholar
Instituição Corp Invest Biol
Univ Los Andes
Univ Antioquia
Universidade Federal de São Paulo (UNIFESP)
Venezuelan Inst Sci Res IVIC
Universidade de São Paulo (USP)
Univ Calif Berkeley
Resumo Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis, a disease confined to Latin America and of marked importance in the endemic areas due to its frequency and severity. This species is considered to be clonal according to mycological criteria and has been shown to vary in virulence. To characterize natural genetic variation and reproductive mode in this fungus, we analyzed P. brasiliensis phylogenetically in search of cryptic species and possible recombination using concordance and nondiscordance of gene genealogies with respect to phylogenies of eight regions in five nuclear loci. Our data indicate that this fungus consists of at least three distinct, previously unrecognized species: S1 (species 1 with 38 isolates), PS2 (phylogenetic species 2 with six isolates), and PS3 (phylogenetic species 3 with 21 isolates). Genealogies of four of the regions studied strongly supported the PS2 clade, composed of five Brazilian and one Venezuelan isolate. the second clade, PS3, composed solely of 21 Colombian isolates, was strongly supported by the alpha-tubulin genealogy. the remaining 38 individuals formed S1. Two of the three lineages of P. brasiliensis, S1 and PS2, are sympatric across their range, suggesting barriers to gene flow other than geographic isolation. Our study provides the first evidence for possible sexual reproduction in P. brasiliensis S1, but does not rule it out in the other two species.
Palavra-chave phylogenetic species
cryptic speciation
recombination
Paracoccidioides brasiliensis
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Molecular Biology and Evolution. Oxford: Oxford Univ Press, v. 23, n. 1, p. 65-73, 2006.
ISSN 0737-4038 (Sherpa/Romeo, fator de impacto)
Publicador Oxford Univ Press
Extensão 65-73
Fonte http://dx.doi.org/10.1093/molbev/msj008
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000233843900010
Endereço permanente http://repositorio.unifesp.br/handle/11600/28604

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