Nutritional parameters and mortality in incident hemodialysis patients

Nutritional parameters and mortality in incident hemodialysis patients

Autor Araújo, Isabel Cristina de Autor UNIFESP Google Scholar
Kamimura, Maria Ayako Autor UNIFESP Google Scholar
Draibe, Sergio Antonio Autor UNIFESP Google Scholar
Canziani, Maria Eugênia Fernandes Autor UNIFESP Google Scholar
Manfredi, Sílvia Regina Autor UNIFESP Google Scholar
Avesani, Carla Maria Autor UNIFESP Google Scholar
Sesso, Ricardo de Castro Cintra Autor UNIFESP Google Scholar
Cuppari, Lilian Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: To evaluate the impact of nutritional parameters at the time of initiation of hemodialysis (HD) on mortality.Design: Retrospective study.Setting: Dialysis Unit of the Federal University of São Paulo, Oswaldo Ramos Foundation.Patients: Three hundred forty-four incident HD patients (60.5% male, 26% diabetic) with the first nutritional evaluation performed before completing 3 months of onset of HD were included.Methods: the study consisted of baseline measurements of several nutritional parameters (triceps skinfold thickness [TSF], midarm muscle circumference [MAMC], body mass index [BMI], serum albumin, serum creatinine, and protein and energy intake assessed by 3-day food diary) and records of outcome (death) over a period of 10 years.Results: Muscle and/or fat depletion was observed in 51% of the studied patients, according to the percent standard of MAMC and TSF, respectively. Presence of diabetes, age over 60 years, serum albumin < 3.5 g/dL, MAMC adequacy < 90%, protein intake < 1.0 g/kg/d, and energy intake < 25 kcal/kg/d were associated with worse survival. When patients were analyzed according to tertiles of dialysis vintage, BMI >= 25 (calculated as kg/m(2)) had a negative impact on survival only in the highest tertile (> 2.45 years). Patients with BMI < 25 and MAMC adequacy : 90% showed the best survival over the study period, and those with BMI >= 25 but MAMC adequacy < 90% had the worst survival (P = .004). in the multivariate survival analysis adjusting for diabetes, advanced age, and hypoalbuminemia, the reduced MAMC (P = .008) and the low energy intake (P = .03) were independent predictors of death in incident HD patients.Conclusions: Reduced MAMC and low energy intake at the beginning of chronic dialysis are risk factors for mortality. A negative effect of high BMI on survival was associated with reduced MAMC and longer dialysis vintage. (c) 2006 by the National Kidney Foundation, Inc.
Idioma Inglês
Data 2006-01-01
Publicado em Journal of Renal Nutrition. Philadelphia: W B Saunders Co-Elsevier Inc, v. 16, n. 1, p. 27-35, 2006.
ISSN 1051-2276 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 27-35
Fonte http://dx.doi.org/10.1053/j.jrn.2005.10.003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000235036200004
URI http://repositorio.unifesp.br/handle/11600/28603

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