Characterization of the rapid-onset type of behavioral sensitization to amphetamine in mice: Role of drug-environment conditioning

Characterization of the rapid-onset type of behavioral sensitization to amphetamine in mice: Role of drug-environment conditioning

Autor Chinen, Cibele Cristina Google Scholar
Faria, Rulian Ricardo Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo A rapid-onset type of behavioral sensitization (ROBS) has been demonstrated in rats treated with a single 'priming' injection of amphetamine (AMP). in that species, however, this phenomenon was restricted to AMP-induced stereotyped behavior (SB), not occurring for the locomotor-stimulant effect (LSE) of AMP and not reflecting environment-specific sensitization. in the present study, the ROBS was characterized in the mouse. Mice received a single 'priming' intraperitoneal injection of 5.0 mg/kg AMP which was paired or not with environment. At different intervals (3, 4 or 5 h) subgroups were tested for AMP (1.5 or 5.0 mg/kg)-induced SB or AMP (1.5 mg/kg)-induced open-field LSE. Results showed that: (1) in the absence of drug-environment association, a priming injection of AMP increased the SB induced by a 1.5 mg/kg AMP challenge injection given 3 h (but not 4 or 5 h) later; (2) when the dose of AMP challenge injection was increased to 5.0 mg/kg, an enhancement of SB was verified at all the intervals tested (3, 4, and 5 h); (3) when animals were tested in an open field, the priming injection of AMP produced an increase in the LSE of a 1.5 mg/kg AMP challenge injection, given 4 h later; (4) drug-environment association increased both SB and locomotion after a saline challenge injection and potentiated the rapid-onset sensitization of both behaviors in AMP-challenged mice. Collectively, these results demonstrate that the ROBS phenomenon also occurs in mice, is extended to AMP-induced LSE, and is markedly potentiated by (but does not depend on) environmental conditioning.
Palavra-chave amphetamine
conditioning
stereotypy
locomotion
behavioral sensitization
Idioma Inglês
Data de publicação 2006-01-01
Publicado em Neuropsychopharmacology. London: Nature Publishing Group, v. 31, n. 1, p. 151-159, 2006.
ISSN 0893-133X (Sherpa/Romeo, fator de impacto)
Publicador Nature Publishing Group
Extensão 151-159
Fonte http://dx.doi.org/10.1038/sj.npp.1300789
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000236132000014
Endereço permanente http://repositorio.unifesp.br/handle/11600/28602

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