Behavioral changes resulting from the administration of cycloheximide in the pilocarpine model of epilepsy

Behavioral changes resulting from the administration of cycloheximide in the pilocarpine model of epilepsy

Autor Santos, J. G. dos Google Scholar
Longo, B. M. Google Scholar
Blanco, M. M. Google Scholar
Oliveira, MGM de Google Scholar
Mello, LEN Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Cycloheximide influences synaptic reorganization resulting from pilocarpine-induced status epilepticus (SE). To investigate the possible behavioral consequences of this effect, we subjected animals to pilocarpine-induced SE either in the absence (Pilo group) or presence of cycloheximide (Chx group). Animals were further divided regarding the occurrence of spontaneous recurrent seizures (SRS). Two months after SE induction animals were exposed to different behavioral tests. Age-matched naive animals were used as controls. All epileptic groups showed a significantly diminished freezing time in contextual and tone fear conditioning, performed poorly in the Morris water maze and present less seconds in immobility position as compared to controls. Only Pilo animals explored more extensively the open arms of the elevated plus maze and showed increased in horizontal exploratory activity in the open field as compared to controls. With the exception of Pilo animals without recorded SRS, all other groups had extensive tissue shrinkage in central nucleus of the amygdala as compared to controls. Cycloheximide-treated animals differed from Pilo animals in the extent of hilar loss and supragranular mossy fiber sprouting as well as tissue shrinkage in the dorsal hippocampus. Despite the histological differences seen in the dorsal hippocampus between experimental groups, no differences were encountered in the cognitive tests used to evaluate dorsal hippocampal function. the encountered histological differences between Chx and Pilo animals, however, might underlie the different emotional responses between the two groups. (c) 2005 Elsevier B.V. All rights reserved.
Palavra-chave temporal lobe epilepsy
Mossy fiber sprouting
Idioma Inglês
Data de publicação 2005-12-20
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 1066, n. 1-2, p. 37-48, 2005.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 37-48
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000234354400005
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