Perinatal outcomes and the use of oral hypoglycemic agents

Perinatal outcomes and the use of oral hypoglycemic agents

Autor Bertini, A. M. Google Scholar
Silva, J. C. Google Scholar
Taborda, W. Google Scholar
Becker, F. Google Scholar
Bebber, FRL Google Scholar
Viesi, JMZ Google Scholar
Aquim, G. Google Scholar
Ribeiro, T. E. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Joinville Reg Univ
Resumo Objective: To compare neonatal results from patients with gestational diabetes mellitus (GDM) who were treated with insulin, glyburide and acarbose.Results: Seventy patients diagnosed with GDM who needed therapy to complement diet and physical activities were included in the study. One group was assigned to insulin therapy (n=27), a second group was assigned to glyburide therapy (n=24) and a third group was assigned to acarbose therapy (n=19). Maternal characteristics were similar in the three groups. Glucose control was not achieved in five (20.8%) of the patients using glyburide and in eight (42.1%) of patients using acarbose. No statistical difference was observed in fasting and post-prandial glucose levels or in average newborn weight in the three groups. the rate of large for gestational age (LGA) fetuses was 3.7, 25 and 10.5% in the groups treated with insulin, glyburide and acarbose, respectively. Neonatal hypoglycemia was observed in eight newborns, six of which from the glyburide group.Conclusion: We believe that glyburide and acarbose can be promising alternative therapies for the treatment of GDM. Glyburide controlled glucose levels in most patients and it was more efficient than acarbose. Glyburide showed a higher rate of macrosomia and neonatal hypoglycemia as compared to other therapies.
Palavra-chave acarbose
gestational diabetes mellitus
oral hypoglycemic agents
Idioma Inglês
Data de publicação 2005-12-01
Publicado em Journal of Perinatal Medicine. Berlin: Walter de Gruyter & Co, v. 33, n. 6, p. 519-523, 2005.
ISSN 0300-5577 (Sherpa/Romeo, fator de impacto)
Publicador Walter de Gruyter & Co
Extensão 519-523
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000233965200008
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